Thus, suggesting that P15 has potential as an anti-metastatic therapy in pancreatic cancer.<b>Implications:</b> This study reveals that anti-vimentin RNA aptamers selected via blind-SELEX inhibit the tumor cell metastasis.<i></i>.
A panel of human carcinomas of the exocrine pancreas orthotopically implanted and perpetuated in nude mice and pancreatic cancer cell lines were studied. p15 gene alterations, mainly homozygous deletions that involved exons 1 and/or 2, were found in the 62.5% (5 of 8) of pancreatic xenografts whereas Smad4 gene aberrations were found in one of eight xenografts and in two of seven cell lines.
These findings suggest that alterations in the p53, p16, and p15 genes are common in human pancreatic cancer cell lines, while p53 or RB mutations are common in hepatoma cell lines.