|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since there has been no report on SLCO1B1 polymorphism in relation with hyperbilirubinemia in Indonesia, this study aims to explore incidence of SLCO1B1*1B polymorphism in Indonesia based on 3 hospitals from different provinces and population, and their association with hyperbilirubinemia severity.
|
31253110 |
2019 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although we have found quite a large number of genetic variants of the UGT1A1 and SLCO1B1 genes in the AA population, it does not appear that they have a significant impact on the incidence of hyperbilirubinemia among this group of infants.
|
27977017 |
2017 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are several reports in literature that inhibition of organic anion transporting polypeptides 1B1 and 1B3 (OATP1B1 and OATP1B3) might lead to hyperbilirubinemia.
|
28063966 |
2017 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggested that Gly71Arg and Asn130Asp mutations in UGT1A1 and OATP2 genes might be involved in the development of hyperbilirubinemia in neonates.
|
26960716 |
2016 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
UGT1A1 promoter TATA-box and SLCO1B1 rs4149056 genotyping was performed to rule out individuals predisposed to hyperbilirubinemia.
|
26191226 |
2015 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, the SLCO1B1 and SLCO1B3 polymorphisms also contributed to an increased risk of hyperbilirubinemia.
|
26146841 |
2015 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no significant differences in SLCO1B1 463 C>A between the hyperbilirubinemia and the control group.
|
23850112 |
2014 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A prospective study was designed to investigate the effects of birth weight, mode of delivery, cephalohematoma, glucose-6-phosphate dehydrogenase (G6PD) deficiency, predischarge total serum bilirubin, variant uridine 5'diphospho-glucuronosyltransferase 1A1 (UGT1A1) gene, and hepatic solute carrier organic anion transporter 1B1 (SLCO1B1) gene on significant hyperbilirubinemia in term breast-fed neonates.
|
23857295 |
2013 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no significant differences in SLCO1B1 521 T > C between the hyperbilirubinemia and the control group (RR, 1.00; 95% CI, 0.72-1.40).
|
24090270 |
2013 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphic forms of 388 nucleotide of the OATP-2 gene were identified as risk factors for hyperbilirubinemia of unknown etiology.
|
21500146 |
2011 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A prospective study was conducted to investigate the effects of birth body weight, sex, mode of delivery, glucose-6-phosphate dehydrogenase (G6PD) deficiency, variant UDP-glucuronosyltransferase 1A1 (UGT1A1) gene, and hepatic solute carrier organic anion transporter 1B1 (SLCO1B1) gene on hyperbilirubinemia in neonates who were breast-fed.
|
21592495 |
2011 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, polymorphisms across three genes involved in bilirubin production and metabolism [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia.
|
20022574 |
2010 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the UGT1A1 gene, SLCO1B1 gene and GST gene have been associated with significant hyperbilirubinemia.
|
19397531 |
2009 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether glucose-6-phosphate dehydrogenase (G6PD), uridine-diphosphoglucuronosyltransferase 1A1 (UGT1A1), and hepatic solute carrier organic anion transporter 1B1 (SLCO1B1) gene variants occur at greater frequency in neonates with significant hyperbilirubinemia.
|
19858149 |
2009 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The results indicated that G6PD deficiency, variant UGT1A1 gene and variant OATP2 gene were risk factors for hyperbilirubinemia.
|
15864125 |
2005 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that G6PD deficiency, variant UGT1A1 gene and variant OATP2 gene were risk factors for hyperbilirubinemia.
|
15864125 |
2005 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, neonates who carry the 211 and 388 variants in the UGT1A1 and OATP 2 genes, respectively, as well as feed with breast milk are at high risk to develop severe hyperbilirubinemia.
|
15319464 |
2004 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, neonates who carry the 211 and 388 variants in the UGT1A1 and OATP 2 genes, respectively, as well as feed with breast milk are at high risk to develop severe hyperbilirubinemia.
|
15319464 |
2004 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
We further provide evidence that the calculated fraction of OATP1B1 inhibited at the clinical exposure level correlated very well with the observed hyperbilirubinemia outcome for these drugs in humans.
|
15535988 |
2004 |