PDLIM5, PDZ and LIM domain 5, 10611

N. diseases: 148; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Nevertheless, after the western blot validation only two of the remaining proteins, namely LIM and SH3 domain protein1, and short-chain specific acyl-CoA dehydrogenase mitochondrial protein, resulted in being significantly upregulated in PBD samples suggesting additional mechanisms that could be associated with the psychotic features of bipolar disorder. 24554194 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it's expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression. 23593136 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration. 23031404 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration. 23031404 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder. 19448850 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder. 19448850 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder. 18456508 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE PDLIM5 may have a minor effect on susceptibility to BP in Caucasians. 18496208 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease LHGDN Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder. 18496210 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder. 18496210 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. 16044170 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease LHGDN These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. 16044170 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease LHGDN In addition, we found the altered expression of LIM and HSPF1 both in the brains and lymphoblastoid cells in bipolar disorder. 14743183 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. 15362566 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE The LIM and SH3 domain protein (LASP1) protein, a component of CNS synapses and dendritic spines, has been related to the N-methyl-D-aspartate receptor (NMDAR) dysfunction hypothesis and schizophrenia. 31827227 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease PSYGENET Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease PSYGENET Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia. 18021463 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease LHGDN Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia. 18021463 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia. 18021463 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE The postsynaptic density-95/discs large/zone occludens-1 (PDZ) domain and LIM (Lin-11, Isl-1, and Mec-3) domain 5 (PDLIM5) gene has been analyzed as a candidate gene for both schizophrenia and bipolar disorder (BP) in Japanese samples. 18496208 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Further, we failed to find any genetic association between the PDLIM5 gene and schizophrenia with six single nucleotide polymorphics (SNPs) of the PDLIM5 gene in Japanese subjects (279 subjects each) and there was no significant relation between PDLIM5 gene and schizophrenia with the haplotype analysis (P=0.48), either. 17287082 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease PSYGENET Further, we failed to find any genetic association between the PDLIM5 gene and schizophrenia with six single nucleotide polymorphics (SNPs) of the PDLIM5 gene in Japanese subjects (279 subjects each) and there was no significant relation between PDLIM5 gene and schizophrenia with the haplotype analysis (P=0.48), either. 17287082 2007