|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether ELISAs based on NS1 proteins of other DENV serotypes can discriminate various DENV and ZIKV infections remains unknown.
|
30429254 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the new FRET-based serological approaches based on NS1 protein are applicable to diagnosing zika virus infections in travelers and differentiating them from other flavivirus infections.
|
31335898 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that monoclonal antibodies targeting the Zika virus nonstructural NS1 protein are protective without inducing antibody-dependent enhancement of disease.
|
30940710 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dynamic behavior of Dengue and Zika viruses NS1 protein reveals monomer-monomer interaction mechanisms and insights to rational drug design.
|
31594455 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the antibody library generated from this cell line, we successfully obtained monoclonal antibodies against the NS1 protein of Zika virus.
|
31240617 |
2019 |
|
Zika Virus Infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we developed a high-throughput and multiplex IgG microsphere immunoassay (MIA) using the NS1 proteins of DENV1-DENV4, ZIKV and West Nile virus (WNV) to test samples from reverse-transcription-polymerase-chain reaction-confirmed cases, including primary DENV1, DENV2, DENV3, WNV and ZIKV infections, secondary DENV infection, and ZIKV infection with previous DENV infection.
|
31442225 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using an IgG capture ELISA, we investigated the kinetics of nonstructural protein 1 (NS1) antibody response during natural ZIKV infection and the cross-reactivity to NS1 proteins using convalescent sera obtained from patients infected by either DENV or ZIKV.
|
29898684 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this case study focused on a computationally predicted Zika virus NS1 protein putative antigenic region, we reached a diagnostic confidence by the oriented and spatially controlled coimmobilization of peptide sequences found adjacent within the protein fold, that cooperatively interacted to provide enhanced immunoreactivity with respect to single linear epitopes.
|
29570266 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study we evaluated the strategy of combination of HHP and alkaline pH on the solubilization of IB using as a model an antigenic form of the zika virus (ZIKV) non-structural 1 (NS1) protein.
|
30541520 |
2018 |
|
Zika Virus Infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection.
|
29379028 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell epitope sequences from Zika virus (ZIKV) NS1 protein have been identified using epitope prediction tools.
|
30023708 |
2017 |
|
Zika Virus Infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated.
|
28876359 |
2017 |