|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus.
|
31754723 |
2020 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on the influenza A virus NS1 protein and outlines current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.
|
31154753 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we identify the NS1 protein as a potential trigger of the epigenetic deregulation of JAK-STAT signaling suppressors and illustrate a novel mechanism underlying the regulation of host immunity during IAV infection.
|
30651365 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis.
|
31470040 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
This research also contributes to a deeper comprehension and insight into the evolutionary dynamics of influenza A NS1 protein.
|
31104825 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.
|
30617221 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that UAP56 also co-localizes with the influenza A viral NS1 protein, which counteracts host cell innate immune responses stimulated by virus infection.
|
30258431 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data further suggest that NS1 also posttranscriptionally alters RIG-I pre-mRNA processing by binding to the RIG-I pre-mRNA.<b>IMPORTANCE</b> A key virulence factor of influenza A virus is the NS1 protein, which inhibits various cellular processes to facilitate viral gene expression.
|
30258002 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Like NS1 protein of Influenza A virus, s8ORF2 of ISAV is implicated in interferon antagonism and RNA-binding functions.
|
29218433 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we showed that influenza A virus NS1 protein inhibits the formation of autophagosomes.
|
30619194 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Like all FLUAV NS1 proteins, bat FLUAV NS1s bind double-stranded RNA and act as interferon antagonists.
|
29237829 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results revealed a novel mechanism by which the NS1 protein of the 2009 pandemic H1N1 suppresses NLRP3 inflammasome activation.<b>IMPORTANCE</b> Influenza A virus (IAV) infection activates the NLRP3 inflammasome, resulting in the production of IL-1β, which contributes to the host innate immune response.
|
29386291 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the NS1 protein of bat influenza A-like viruses is less efficient than the NS1 protein of its conventional influenza A virus NS1 counterpart in antagonizing the IFN response and that this deficiency can be overcome by the influenza virus PB2 protein.<b>IMPORTANCE</b> Significant gaps in our understanding of the basic features of the recently discovered bat influenza A-like viruses HL17NL10 and HL18NL11 remain.
|
29321309 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These changes occur at the ends of highly transcribed genes, where global inhibition of transcription termination by IAV NS1 protein causes readthrough transcription for hundreds of kilobases.
|
30146161 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, a number of mammalian VSRs have been described, of which the most prominent is the influenza A virus (IAV) NS1 protein, which has not only been reported to inhibit RNAi in plants and insects but also to prevent the production of viral siRNAs in IAV-infected human cells.
|
29903832 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza A virus non-structural-1A binding protein (named as Ns1abp) was originally identified as a host protein from human that bound to the viral NS-1 protein.
|
29510164 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The study has demonstrated, for the first time, the expression of nonstructural 1 (NS1) protein of influenza A virus H5N1 on the cell wall of Lactobacillus casei using the pSGANC332 expression plasmid.
|
28370088 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
A naturally truncated NS1 protein of influenza A virus impairs its interferon-antagonizing activity and thereby confers attenuation in vitro.
|
27400993 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that the interaction between NS1 protein of influenza A/Shantou/602/06 (H3N2) and nucleolin, a ubiquitous protein of nucleolus repressed RNA Pol I-dependent transcription via establishing hyper-methylation in the UCE of rRNA gene promoter.
|
29259342 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response.
|
27914808 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked.
|
28076660 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Non-linear enhancement of mRNA delivery efficiencies by influenza A derived NS1 protein engendering host gene inhibition property.
|
28426973 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study used a clone of the NS1 gene from avian influenza A/Jiangsu/1/2007 and observed the localization of the NS1 protein and cytochrome <i>c</i> release from mitochondria and the change of mitochondrial membrane potential (MMP) in lung cancer cells.
|
29067097 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pleiotropic NS1 protein of influenza A virus acts as silencer of PKR activation and ensures high-level viral replication and virulence.
|
28250123 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions.
|
28837667 |
2017 |