PDPN, podoplanin, 10630

N. diseases: 256; N. variants: 3
Disease: Brain Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 AlteredExpression group BEFREE In addition, expression of the glycoprotein podoplanin on brain tumors was associated with both intratumoral thrombi and high risk of VTE. 31041803 2019
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 AlteredExpression group BEFREE Podoplanin is expressed in certain types of tumor cells, including squamous cell carcinomas, seminomas, and brain tumors. 29863945 2018
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 AlteredExpression group BEFREE Patients with wild-type IDH1 brain tumors and high podoplanin expression had a significantly increased VTE risk compared with those with mutant IDH1 tumors and no podoplanin expression (6-month risk 18.2% vs. 0%). 29676036 2018
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 Biomarker group BEFREE Since podoplanin is associated with VTE risk in brain tumor patients, it could be a useful biomarker to identify patients at very high VTE risk. 29703483 2018
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 AlteredExpression group BEFREE Podoplanin expression is associated with VTE in patients with brain cancer and may activate platelets. 28807983 2017
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 Biomarker group BEFREE Key messages Podoplanin, a protein linked to the promotion of human brain tumors, is required in vivo for proper hippocampus-dependent learning and memory functions. 27558977 2016
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 AlteredExpression group BEFREE Expression of podoplanin in glial brain tumors is grade dependent. 26339454 2015
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.080 AlteredExpression group BEFREE Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation. 22394497 2012