Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs).
|
31731479 |
2019 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis showed patients with high periostin level had a lower risk of asthma exacerbation after receiving anti-IL-13 treatment.
|
30703143 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The mean ± standard deviation (SD) serum periostin concentration in patients with asthma was 90.36 ± 19.81 ng/mL, which was significantly higher (p < 0.01) compared with healthy controls (31.88 ± 8.71 ng/mL).
|
30582493 |
2019 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EBC and serum ezrin levels correlated with lung function in patients with asthma and serum ezrin levels were negatively correlated with serum IL-13 and periostin.
|
30290132 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of diagnostic and predictive biomarkers (e.g., IgE, blood eosinophil count, FeNO, periostin, etc.) has revolutioned the field of targeted therapy in severe asthma.
|
29318959 |
2019 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The serum levels of EDN and periostin were significantly higher in severe asthmatics than in nonsevere asthmatics and in healthy controls (all <i>P</i> < 0.05).
|
30912328 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heterogeneity might be caused by non-threshold effect.<b>Conclusion</b>: Periostin has moderate accuracy in the diagnosis of asthma.
|
31738608 |
2019 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum periostin levels were better associated with fixed airflow limitation (FEV<sub>1</sub>/FVC ratio <70%) than FeNO levels, blood eosinophil counts or total IgE levels in the asthmatics.
|
29648484 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice.
|
31047107 |
2019 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Those with asthma had higher serum interferon (IFN)-α, but lower serum tumour necrosis factor, interleukin (IL)-5, IL-6, CXCL8, CXCL9, IL-10, IL-17 and CCL2 levels (all p<0.05); both groups had similar serum IL-13, total IgE, periostin and blood eosinophil gene expression levels.
|
31391224 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum periostin concentration inversely correlated with BMI and age not only in asthma patients but also in controls.
|
31496317 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Objectives: The aims of the study were to estimate the percentage of cases of uncontrolled severe asthma (UcSA) in children with poorly controlled asthma and to evaluate the role of periostin as a biomarker.
|
28128098 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The biomarkers considered were blood eosinophil counts, fractional exhaled nitric oxide (FeNO), serum dipeptidyl peptidase-4, serum periostin and total serum immunoglobulin E. Tralokinumab efficacy was measured as the reduction in annualised asthma exacerbation rate (AAER) compared with placebo (primary endpoint measure of STRATOS 1 and 2).
|
31315668 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum periostin may significantly help to improve management of patients with severe asthma.
|
31037633 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Periostin is induced in bronchial epithelial cells and fibroblasts by various stimuli including interleukin (IL)13 and transforming growth factor (TGF)-β1, and is involved in allergic diseases such as asthma and atopic dermatitis, playing an important role in tissue remodeling and fibrosis.
|
31012597 |
2019 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum periostin levels correlated weakly with eosinophil counts in asthma, ACO, and COPD.
|
29981861 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These miRNAs can classify asthmatics into two clusters that differed in the number of eosinophils and periostin concentration in serum.
|
30040124 |
2019 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial.
|
30612125 |
2019 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The serum periostin concentrations were also correlated with the serum IgE concentrations (r = 0.375, p = 0.003)and FeNO levels (r = 0.291, p = 0.024) in patients with asthma.
|
29035604 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Periostin, a biomarker that reflects Th2-driven inflammatory diseases such as asthma, may play an important role in the asthmatic airway.
|
29342461 |
2018 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to compare serum periostin levels in recurrent wheezer pre-schoolers according to their asthma predictive index (API) condition.
|
29279258 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that periostin is measurable in the airways and increased in patients with severe asthma, especially in those from the T2 endotype.
|
30336944 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Asthmatics with persistent airflow obstruction had greater airway smooth muscle (Asm) area with decreased periostin and transforming growth factor beta-positive cells within Asm bundles, in addition to lower numbers of chymase-positive mast cells in the submucosa compared to patients with nonpersistent obstruction.
|
28960335 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first study to show that serum TNC levels in asthmatic patients are associated with clinical features of asthma and that the combination of serum TNC and periostin levels or combination of serum TNC and total IgE levels were more useful for asthma than each single marker, suggesting that serum TNC can serve as a novel biomarker for asthma.
|
30473714 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Periostin is a matricellular protein implicated in type 2 immunity-driven asthma.
|
30450856 |
2018 |