POSTN, periostin, 10631

N. diseases: 378; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease BEFREE These data suggested that Postn has an anti-tumor effect on colitis-induced colorectal cancer. 29731999 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease BEFREE Conclusively, stromal POSTN is prognostic and predictive for CRC via creating a niche to facilitate cancer progression. 26556874 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease BEFREE Twelve of 15 patients (80%) had positive immunohistochemical periostin staining in CRC samples. 19212687 2009
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease CTD_human The results demonstrate the growth-promoting properties of periostin, and a possible role of targeting this protein as a therapeutic option in colorectal cancers. 15731169 2005
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
0.310 Biomarker disease CTD_human We also examined periostin expression in neonatal lung mesenchymal stromal cells and lung tissue of hyperoxia-exposed neonatal mice and human infants with BPD. 22363622 2012
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
0.310 AlteredExpression disease BEFREE We also examined periostin expression in neonatal lung mesenchymal stromal cells and lung tissue of hyperoxia-exposed neonatal mice and human infants with BPD. 22363622 2012
CUI: C1319853
Disease: Asthma, Aspirin-Induced
Asthma, Aspirin-Induced
0.310 Biomarker disease BEFREE Immunohistochemistry revealed positive staining for pendrin in epithelial cells and submucosal glands and for periostin in the basement membrane in all three disorders, and additionally for periostin in nasal polyp tissue in chronic rhinosinusitis and aspirin-induced asthma. 22918213 2012
CUI: C1319853
Disease: Asthma, Aspirin-Induced
Asthma, Aspirin-Induced
0.310 Biomarker disease CTD_human Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma. 18391768 2008
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne
0.300 Biomarker disease CTD_human Inhibiting TGF-β activity improves respiratory function in mdx mice. 21641384 2011
CUI: C0917713
Disease: Becker Muscular Dystrophy
Becker Muscular Dystrophy
0.300 Biomarker disease CTD_human Inhibiting TGF-β activity improves respiratory function in mdx mice. 21641384 2011
Duchenne and Becker Muscular Dystrophy
0.300 Biomarker disease CTD_human Inhibiting TGF-β activity improves respiratory function in mdx mice. 21641384 2011
CUI: C0013182
Disease: Drug Allergy
Drug Allergy
0.300 Biomarker group CTD_human Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma. 18391768 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.300 Biomarker group CTD_human Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. 15731169 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 AlteredExpression disease BEFREE Furthermore, periostin was upregulated in response to MI, whereas olmesartan blocked this upregulation. 29872491 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 Biomarker disease BEFREE Neonatal periostin-knockout mice and their wildtype littermates were subjected to MI or sham surgery. 28453729 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 Biomarker disease BEFREE We observed that deletion of Tgfbi did not alter cardiac disease after myocardial infarction in contrast to greater ventricular wall rupture in Postn gene-deleted mice. 28750100 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 AlteredExpression disease BEFREE Systemic injection of AAV9 carrying a periostin promoter targets gene expression to a myofibroblast-like lineage in mouse hearts after reperfused myocardial infarction. 26926804 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 AlteredExpression disease BEFREE Periostin, an extracellular matrix protein, is expressed in injured tissues, such as the heart with myocardial infarction, and promotes angiogenesis and tissue repair. 24834847 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 Biomarker disease RGD With regard to the extracellular matrix variables, the myocardial infarction group presented with higher values of periostin and types I and III collagen and higher interstitial collagen volume fractions and myocardial hydroxyproline concentrations. 24212842 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 AlteredExpression disease LHGDN Periostin is essential for cardiac healing after acute myocardial infarction. 18208976 2008
CUI: C0018801
Disease: Heart failure
Heart failure
0.250 Biomarker disease BEFREE Unbiased as well as targeted gene expression and pathway analyses identified periostin, angiotensin signaling, and IGF-1 signaling as potential causes of increased HF susceptibility in C57BL/6J mice and as potentially useful drug targets for HF treatment. 29288409 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.250 Biomarker disease BEFREE Unbiased as well as targeted gene expression and pathway analyses identified periostin, angiotensin signaling, and IGF-1 signaling as potential causes of increased HF susceptibility in C57BL/6J mice and as potentially useful drug targets for HF treatment. 29288409 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.250 Biomarker disease BEFREE Up-regulation was evident for muscle LIM protein (Mlp), desmin, and heart failure (natriuretic peptide A [Nppa], Nppb, and myosin heavy chain 6) and fibrosis (transforming growth factor beta 1, alpha-smooth muscle actin, osteopontin, and periostin) markers. 25541130 2014
CUI: C0018801
Disease: Heart failure
Heart failure
0.250 Biomarker disease BEFREE Periostin, the distribution and expression of which were consistent with the extent of myocardial fibrosis, might be a potential biomarker of cardiac remodeling in heart failure patients. 24219836 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.250 Biomarker disease BEFREE Up-regulation was evident for muscle LIM protein (Mlp), desmin, and heart failure (natriuretic peptide A [Nppa], Nppb, and myosin heavy chain 6) and fibrosis (transforming growth factor beta 1, alpha-smooth muscle actin, osteopontin, and periostin) markers. 25541130 2014