Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
The analysis identified a cluster of transcripts associated with Sjögren's foci, including messenger RNAs (mRNAs) for C⁻X⁻C motif chemokine ligand 13 (CXCL13) and B-cell activating factor (BAFF), which dominated the major principal component.
|
30626116 |
2019 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
Emerging soluble biomarkers for SS related lymphoma include mediators of B cell growth and germinal center formation such as BAFF, FMS-like tyrosine kinase 3 ligand (Flt-3L) and CXCL13 as well as inflammatory contributors such as inteleukin (IL)-17, IL-18, ASC, LILRA3 and the extracellular lipoprotein-associated phospholipase A2 (Lp-PLA2).
|
31444033 |
2019 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
Expression of the DEGs IFNG and BAFF increased in SGs from patients with primary SS, as assessed by focus score.
|
29927095 |
2018 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjögren's syndrome as a proof of concept.
|
24304965 |
2014 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activation of the type I interferon/B cell-activating factor axis in SS has recently attracted particular attention.
|
24050623 |
2014 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogren's syndrome and association with disease activity and BAFF gene expression.
|
22736090 |
2013 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Sjögren's syndrome (SS) is an autoimmune disease characterized by clonal B cell attack of the exocrine glands and dysregulated expression of B cell-activating factor (BAFF).
|
20408860 |
2010 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
Finally, BAFF plays a major role in B-cell repopulation after their depletion by rituximab in SS.
|
20457281 |
2010 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome.
|
18617551 |
2008 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
LHGDN |
BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome.
|
17469105 |
2007 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept.
|
18050196 |
2007 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS).
|
17214581 |
2006 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
LHGDN |
Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome.
|
16802367 |
2006 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
LHGDN |
Is periodontal disease mediated by salivary BAFF in Sjögren's syndrome?
|
16052575 |
2005 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome.
|
15981083 |
2005 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjögren's syndrome.
|
15095277 |
2004 |
Sjogren's Syndrome
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Analysis of BLyS plasma levels in Systemic Lupus Erythematosus, Sjogren's Syndrome and Rheumatoid Arthritis (RA) has shown that BLyS is higher in a group of patients than in the controls.
|
15470519 |
2004 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis.
|
11781351 |
2002 |
Sjogren's Syndrome
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|