|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Unlike in hematologic malignancies in which C/EBP mutations and their disruption of wild type C/EBP tumor suppressive activities have been well documented, mutation of C/EBP does not appear to be a common event in gynecologic cancers, raising some doubt if C/EBPs may have tumor suppressor activity in gynecologic cancers.
|
28031014 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of all C/EBP family proteins was decreased in SCC tumors.
|
25402211 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Rescue of KLHL9 expression induced proteasomal degradation of C/EBP proteins, abrogated the mesenchymal signature, and reduced tumor viability in vitro and in vivo.
|
25303533 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In summary, we show that P-cadherin contributes to the keratinocyte differentiation in the oral epithelium by influencing the CK1 and CK10 expression via C/EBP-beta-mediated signaling in normal but not in tumor derived oral keratinocytes from OSCC patients.
|
23142730 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
C/EBP alpha has a crucial role in inducing terminal differentiation and is an established tumor suppressor gene in several cancer models.
|
20386538 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduction of C/EBP alpha was associated with advanced tumor stage (P = 0.001).
|
18663475 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
C/EBP beta is a transcription factor regulating key biological processes including cellular growth and differentiation and its increased expression correlates with tumor invasiveness.
|
18512730 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcription factor CCAAT/enhancer binding protein-alpha (C/EBP alpha) is involved in the control of cell differentiation and proliferation, and has been suggested to act as a tumor suppressor in several cancers.
|
18381421 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additional experiments with tumor tissues revealed that the transcriptional activator C/EBP alpha containing the 1797G allele increased levels of the MDM2 mRNA and protein in bladder tumor tissues.
|
18519798 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo studies further revealed that the PPD was potent in stabilizing MEND in the systemic circulation and facilitating tumor accumulation.Moreover, the i.v. administration of PPD or PEG/PPD dually-modified MEND resulted in the stimulation of pDNA expression in tumor tissue, as compared with a conventional PEG-modified MEND.
|
16915290 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Patients whose expression of C/EBP beta mRNA and protein in tumor tissue was lower survived longer than those whose expressions were higher.
|
16465418 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, C/EBP beta has tumor suppression effect in vivo and may be used in gene therapy for cancers.
|
16246266 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We showed previously that CCAAT/enhancer binding protein alpha (C/EBP alpha), a tissue-specific transcription factor, is a candidate tumor suppressor in lung cancer.
|
15205324 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data imply that the comparison of C/EBP alpha and C/EBP beta expression between tumors and non-tumorous regions could be a prognostic marker for patients with hepatocellular carcinoma.
|
12680236 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We studied the relationship between C/EBP and tumor histology (Duke's invasive stage and pathological grade) in colorectal cancer.
|
10760820 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether C/EBP-epsilon behaves as an altered tumor-suppressor gene, samples from patients with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) evolving to AML were studied for loss of heterozygosity (LOH) using microsatellite sequences that we identified within 0.2 kb of the amino-terminus of the human C/EBP-epsilon gene.
|
9393598 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
C/EBP alpha expressing cells s.c. implanted in CD-1 nu/nu mice were essentially nontumorigenic, whereas C/EBP alpha tumor cells implanted into immunodeficient SCID mice demonstrated a significantly delayed time of tumor appearance compared with cells transfected with a vector control plasmid.
|
8640762 |
1996 |