|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This study aims to investigate the association of 2 single nucleotide polymorphisms (SNPs) in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China.
|
29391274 |
2018 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To understand the prevalence and functional significance of CORIN variants in hypertension, we sequenced CORIN exons in 300 normal and 401 hypertensive individuals in a Chinese population and identified nine nonsynonymous variants, of which eight were not characterized previously.
|
28861913 |
2017 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CORIN variants and mutations impairing corin activation have been identified in people with hypertension and pre-eclampsia.
|
26259032 |
2015 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CORIN variants have been associated with hypertension and heart disease in African Americans.
|
25488193 |
2014 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Here, we report a new mutation in exon 12 of the CORIN gene identified in a family of patients with hypertension.
|
23372161 |
2013 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A corin gene variant (T555I/Q568P) was identified in blacks with hypertension and cardiac hypertrophy.
|
22987923 |
2012 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In humans, single nucleotide polymorphisms in the corin gene have been identified in African Americans with hypertension and cardiac hypertrophy.
|
18716601 |
2009 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
LHGDN |
Thus, our results show that the corin gene SNPs associated with hypertension and cardiac hypertrophy impair corin zymogen activation and natriuretic peptide processing activity.
|
18669922 |
2008 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, our results show that the corin gene SNPs associated with hypertension and cardiac hypertrophy impair corin zymogen activation and natriuretic peptide processing activity.
|
18669922 |
2008 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We recently identified a minor allele in the corin gene defined by 2 highly linked single nucleotide polymorphisms (T555I and Q568P), which was associated with hypertension in blacks.
|
17296875 |
2007 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
LHGDN |
We recently identified a minor allele in the corin gene defined by 2 highly linked single nucleotide polymorphisms (T555I and Q568P), which was associated with hypertension in blacks.
|
17296875 |
2007 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
More recently, single nucleotide polymorphisms (SNPs) are found in the human corin gene, which are associated with an increased risk for hypertension and cardiac hypertrophy.
|
17485366 |
2007 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
LHGDN |
Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.
|
16216958 |
2005 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.
|
16216958 |
2005 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
The demonstrated corin protein expression by heart myocytes supports its proposed role as the pro-ANP convertase, and thus a potentially critical mediator of major cardiovascular diseases including hypertension and congestive heart failure.
|
11082206 |
2000 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|