|
Pre-Eclampsia
|
0.600 |
SusceptibilityMutation
|
phenotype |
ORPHANET |
Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
|
22437503 |
2012 |
|
Pre-Eclampsia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Pre-Eclampsia
|
0.600 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
PREECLAMPSIA/ECLAMPSIA 5
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
|
22437503 |
2012 |
|
PREECLAMPSIA/ECLAMPSIA 5
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Congestive heart failure
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
Here we define in a canine model of HF furin and corin gene and protein expression in normal and failing left atrium (LA) or ventricle (LV) testing the hypothesis that the NP proproteins convertases production is altered in experimental HF.
|
23152112 |
2013 |
|
Congestive heart failure
|
0.220 |
Biomarker
|
disease |
RGD |
Rat corin gene: molecular cloning and reduced expression in experimental heart failure.
|
15155264 |
2004 |
|
Congestive heart failure
|
0.220 |
Biomarker
|
disease |
RGD |
In this study, we examined the regulation of corin gene expression in cultured hypertrophic cardiomyocytes and in the left ventricular (LV) myocardium of a rat model of heart failure.
|
15191894 |
2004 |
|
Congestive heart failure
|
0.220 |
Biomarker
|
disease |
BEFREE |
The demonstrated corin protein expression by heart myocytes supports its proposed role as the pro-ANP convertase, and thus a potentially critical mediator of major cardiovascular diseases including hypertension and congestive heart failure.
|
11082206 |
2000 |
|
Heart failure
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Here we define in a canine model of HF furin and corin gene and protein expression in normal and failing left atrium (LA) or ventricle (LV) testing the hypothesis that the NP proproteins convertases production is altered in experimental HF.
|
23152112 |
2013 |
|
Cardiomegaly
|
0.210 |
GeneticVariation
|
phenotype |
LHGDN |
Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.
|
18669922 |
2008 |
|
Cardiomegaly
|
0.210 |
Biomarker
|
phenotype |
RGD |
Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium.
|
15191894 |
2004 |
|
Heart failure
|
0.210 |
Biomarker
|
disease |
RGD |
In this study, we examined the regulation of corin gene expression in cultured hypertrophic cardiomyocytes and in the left ventricular (LV) myocardium of a rat model of heart failure.
|
15191894 |
2004 |
|
Heart failure
|
0.210 |
Biomarker
|
disease |
RGD |
Rat corin gene: molecular cloning and reduced expression in experimental heart failure.
|
15155264 |
2004 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This study aims to investigate the association of 2 single nucleotide polymorphisms (SNPs) in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China.
|
29391274 |
2018 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To understand the prevalence and functional significance of CORIN variants in hypertension, we sequenced CORIN exons in 300 normal and 401 hypertensive individuals in a Chinese population and identified nine nonsynonymous variants, of which eight were not characterized previously.
|
28861913 |
2017 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CORIN variants and mutations impairing corin activation have been identified in people with hypertension and pre-eclampsia.
|
26259032 |
2015 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CORIN variants have been associated with hypertension and heart disease in African Americans.
|
25488193 |
2014 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Here, we report a new mutation in exon 12 of the CORIN gene identified in a family of patients with hypertension.
|
23372161 |
2013 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A corin gene variant (T555I/Q568P) was identified in blacks with hypertension and cardiac hypertrophy.
|
22987923 |
2012 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In humans, single nucleotide polymorphisms in the corin gene have been identified in African Americans with hypertension and cardiac hypertrophy.
|
18716601 |
2009 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
LHGDN |
Thus, our results show that the corin gene SNPs associated with hypertension and cardiac hypertrophy impair corin zymogen activation and natriuretic peptide processing activity.
|
18669922 |
2008 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, our results show that the corin gene SNPs associated with hypertension and cardiac hypertrophy impair corin zymogen activation and natriuretic peptide processing activity.
|
18669922 |
2008 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We recently identified a minor allele in the corin gene defined by 2 highly linked single nucleotide polymorphisms (T555I and Q568P), which was associated with hypertension in blacks.
|
17296875 |
2007 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
LHGDN |
We recently identified a minor allele in the corin gene defined by 2 highly linked single nucleotide polymorphisms (T555I and Q568P), which was associated with hypertension in blacks.
|
17296875 |
2007 |