NRG3, neuregulin 3, 10718

N. diseases: 43; N. variants: 42
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE However, no study has investigated the effects of NRG3 polymorphism on cognitive deficits in a large sample of the patients with schizophrenia. 31753594 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Neuregulin-3 (Nrg3) is a member of the Nrg family of growth factors identified as risk factors for schizophrenia. 30328115 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE They were first implicated in schizophrenia in 2002 with the detection of linkage and association at the NRG1 locus followed after a few years by NRG3. 28556469 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE Isoform-specific increases in NRG3 are observed in schizophrenia and associated with rs10748842, a NRG3 risk polymorphism, suggesting NRG3 transcriptional dysregulation as a molecular mechanism of risk. 27771971 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease MGD We propose that KO mice will provide a valuable animal model to determine the role of the NRG3 in the molecular pathogenesis of schizophrenia and other psychotic disorders. 27606322 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE The neuregulin 3 gene (NRG3) plays pleiotropic roles in neurodevelopment and is a putative susceptibility locus for schizophrenia. 24431462 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE The aims of the present study were to extend analysis of the association between NRG3 and psychotic symptoms and attention in schizophrenia and to determine whether these associations also apply to bipolar disorder. 22831755 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Our study provided no evidence that NRG3 confers a risk of schizophrenia susceptibility in the Han Chinese population. 22981155 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Neuregulin 3 (NRG3) as a susceptibility gene in a schizophrenia subtype with florid delusions and relatively spared cognition. 20548296 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE By elucidating a lack of association in a Korean population, findings from this study may contribute to the understanding of the genetic etiology focusing on the role of NRG3 in schizophrenia pathogenesis. 21762460 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 AlteredExpression disease BEFREE RNA expression profiling of these isoforms in the prefrontal cortex of 400 individuals revealed that NRG3 expression is developmentally regulated and pathologically increased in schizophrenia. 20713722 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease CTD_human RNA expression profiling of these isoforms in the prefrontal cortex of 400 individuals revealed that NRG3 expression is developmentally regulated and pathologically increased in schizophrenia. 20713722 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 AlteredExpression disease BEFREE NRG3 is primarily expressed in the central nervous system and is one of three paralogs of NRG1, a gene strongly implicated in SZ. 19118813 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 AlteredExpression disease BEFREE These data suggest any change in NRG1Ialpha and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46. 19765633 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE The result supports that the NRG3 gene is a susceptibility gene for schizophrenia. 18708184 2008