Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, no study has investigated the effects of NRG3 polymorphism on cognitive deficits in a large sample of the patients with schizophrenia.
|
31753594 |
2020 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neuregulin-3 (Nrg3) is a member of the Nrg family of growth factors identified as risk factors for schizophrenia.
|
30328115 |
2019 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
They were first implicated in schizophrenia in 2002 with the detection of linkage and association at the NRG1 locus followed after a few years by NRG3.
|
28556469 |
2018 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Isoform-specific increases in NRG3 are observed in schizophrenia and associated with rs10748842, a NRG3 risk polymorphism, suggesting NRG3 transcriptional dysregulation as a molecular mechanism of risk.
|
27771971 |
2017 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
MGD |
We propose that KO mice will provide a valuable animal model to determine the role of the NRG3 in the molecular pathogenesis of schizophrenia and other psychotic disorders.
|
27606322 |
2016 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The neuregulin 3 gene (NRG3) plays pleiotropic roles in neurodevelopment and is a putative susceptibility locus for schizophrenia.
|
24431462 |
2014 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aims of the present study were to extend analysis of the association between NRG3 and psychotic symptoms and attention in schizophrenia and to determine whether these associations also apply to bipolar disorder.
|
22831755 |
2013 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study provided no evidence that NRG3 confers a risk of schizophrenia susceptibility in the Han Chinese population.
|
22981155 |
2013 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neuregulin 3 (NRG3) as a susceptibility gene in a schizophrenia subtype with florid delusions and relatively spared cognition.
|
20548296 |
2011 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
By elucidating a lack of association in a Korean population, findings from this study may contribute to the understanding of the genetic etiology focusing on the role of NRG3 in schizophrenia pathogenesis.
|
21762460 |
2011 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RNA expression profiling of these isoforms in the prefrontal cortex of 400 individuals revealed that NRG3 expression is developmentally regulated and pathologically increased in schizophrenia.
|
20713722 |
2010 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
CTD_human |
RNA expression profiling of these isoforms in the prefrontal cortex of 400 individuals revealed that NRG3 expression is developmentally regulated and pathologically increased in schizophrenia.
|
20713722 |
2010 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
NRG3 is primarily expressed in the central nervous system and is one of three paralogs of NRG1, a gene strongly implicated in SZ.
|
19118813 |
2009 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data suggest any change in NRG1Ialpha and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46.
|
19765633 |
2009 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The result supports that the NRG3 gene is a susceptibility gene for schizophrenia.
|
18708184 |
2008 |
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
NRG3 isoform classes I-IV were quantified using quantitative real-time polymerase chain reaction in human postmortem dorsolateral prefrontal cortex from 286 nonpsychiatric control individuals, from gestational week 14 to 85 years old, and individuals diagnosed with either bipolar disorder (N=34) or major depressive disorder (N=69).
|
27771971 |
2017 |
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The finding of a significant association between rs6584400 and attention performance in bipolar disorder supports the hypothesis that this NRG3 variant confers genetic susceptibility to cognitive deficits in both schizophrenia and bipolar disorder.
|
22831755 |
2013 |
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
The aims of the present study were to extend analysis of the association between NRG3 and psychotic symptoms and attention in schizophrenia and to determine whether these associations also apply to bipolar disorder.
|
22831755 |
2013 |
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder.
|
19765633 |
2009 |
Bipolar I disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
These data suggest any change in NRG1Ialpha and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46.
|
19765633 |
2009 |
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
Epstein-Barr Virus Infections
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.
|
28654678 |
2017 |
Autosomal dominant compelling helio ophthalmic outburst syndrome
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |