|
Perianal Crohn's disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We included 1721 patients with CD of which 524 (30.4%) were pCD+ and 1197 were pPCD. pCD was associated with distal colonic disease (Odds ratio 5.54 [3.23-9.52], P < 0.001), stricturing disease behavior (1.44 [1.14-1.81], P = 0.002) and family history of inflammatory bowel disease (4.98 [3.30-7.46], P < 0.001). pCD was associated with higher anti-sacharomyces cerevisae antibodies IgA (P < 0.001) and OmpC (P = 0.008) antibody levels. pCD was associated with known inflammatory bowel disease loci, including KIF3B, CRTC3, TRAF3IP2, JAZF1, NRIP1, MST1, FUT2, and PTGER (all P < 0.05).
|
26937622 |
2016 |
|
Toxic Epidermal Necrolysis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study suggests that a variant in TRAF3IP2 gene could be involved in susceptibility to SJS/TEN.
|
25775161 |
2015 |
|
Schwartz-Jampel Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study suggests that a variant in TRAF3IP2 gene could be involved in susceptibility to SJS/TEN.
|
25775161 |
2015 |
|
Behcet Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs (rs6540679, rs12569232, rs10863888) of TRAF5 and rs13210247 of TRAF3IP2 were significantly associated with Behçet's disease and VKH syndrome (corrected P values ranging from 9.45×10(-12) to 0.027).
|
24416204 |
2014 |
|
Nasal Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin-17A promotes MUC5AC expression and goblet cell hyperplasia in nasal polyps via the Act1-mediated pathway.
|
24892823 |
2014 |
|
polyps
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We enrolled 25 NP patients and 22 normal controls and examined the expression of IL-17A, MUC5AC and act1 in polyp tissues by immunohistochemical (IHC) staining, quantitative polymerase chain reaction (qPCR) and western blot.
|
24892823 |
2014 |
|
Uveomeningoencephalitic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs (rs6540679, rs12569232, rs10863888) of TRAF5 and rs13210247 of TRAF3IP2 were significantly associated with Behçet's disease and VKH syndrome (corrected P values ranging from 9.45×10(-12) to 0.027).
|
24416204 |
2014 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since CIKS mediates high glucose-induced NF-κB and AP-1-dependent inflammatory signaling and endothelial dysfunction, targeting CIKS may delay progression of vascular diseases during diabetes mellitus and atherosclerosis.
|
23085260 |
2013 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since CIKS mediates high glucose-induced NF-κB and AP-1-dependent inflammatory signaling and endothelial dysfunction, targeting CIKS may delay progression of vascular diseases during diabetes mellitus and atherosclerosis.
|
23085260 |
2013 |
|
Dermatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility.
|
23202271 |
2013 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Since CIKS mediates high glucose-induced NF-κB and AP-1-dependent inflammatory signaling and endothelial dysfunction, targeting CIKS may delay progression of vascular diseases during diabetes mellitus and atherosclerosis.
|
23085260 |
2013 |
|
Irritable Bowel Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first preliminary report indicating that TRAF3IP2 variants increase the risk of cutaneous extraintestinal manifestations in IBD suggesting that the analysis of the TRAF3IP2 variants may be useful for identifying IBD patients at risk to develop these manifestations.
|
22445837 |
2013 |
|
Pyoderma Gangrenosum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We therefore aimed to assess the role of TRAF3IP2 gene in IBD, with particular regard to the development of cutaneous extraintestinal manifestations (pyoderma gangrenosum, erythema nodosum).
|
22445837 |
2013 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Similar to HG, the deleterious metabolic products of chronic hyperglycemia, AGE-HSA, AOPPs-HSA and oxLDL, also induced CIKS-dependent endothelial dysfunction.
|
23085260 |
2013 |
|
Inflammatory dermatosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility.
|
23202271 |
2013 |
|
Mycetoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Morphological and phylogenetic analysis of the ribosomal small subunit (SSU), large subunit (LSU), internal transcribed spacer (ITS), β-tubulin (BT2), actin (ACT1), and elongation factor (TEF1) genes revealed that the isolate deviated from any known agent of mycetoma; it clustered in the genus Pleurostoma (anamorph genus, Pleurostomophora) in the order Calosphaeriales.
|
22760037 |
2012 |
|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Similarly, coordinated elevated Gal3/Cav1 expression was observed in three DTC-derived cell lines (papillary TCP1 and KTC1 and follicular FTC133) but only one (ACT1) of five ATC-derived cell lines.
|
22513979 |
2012 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, Act1 deficiency in epithelial cells reduced the phenotype of allergic pulmonary inflammation due to loss of IL-17-induced neutrophilia and IL-25-induced eosinophilia, respectively.
|
19155512 |
2009 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate the essential role of epithelial-derived Act1 in allergic pulmonary inflammation through the distinct impact of the IL-17R-Act1 and IL-25R-Act1 axes.
|
19155512 |
2009 |
|
Pulmonary Eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although Act1-deficient mice showed reduced expression of KC (CXCL1) and neutrophil recruitment to the airway compared with wild-type mice in response to IL-17 stimulation, Act1 deficiency abolished IL-25-induced expression of IL-4, IL-5, IL-13, eotaxin-1 (CCL11), and pulmonary eosinophilia.
|
19155512 |
2009 |
|
Asthmatic pulmonary eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although Act1-deficient mice showed reduced expression of KC (CXCL1) and neutrophil recruitment to the airway compared with wild-type mice in response to IL-17 stimulation, Act1 deficiency abolished IL-25-induced expression of IL-4, IL-5, IL-13, eotaxin-1 (CCL11), and pulmonary eosinophilia.
|
19155512 |
2009 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Importantly, Act1 deficiency in epithelial cells reduced the phenotype of allergic pulmonary inflammation due to loss of IL-17-induced neutrophilia and IL-25-induced eosinophilia, respectively.
|
19155512 |
2009 |
|
Neutrophilia (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, Act1 deficiency in epithelial cells reduced the phenotype of allergic pulmonary inflammation due to loss of IL-17-induced neutrophilia and IL-25-induced eosinophilia, respectively.
|
19155512 |
2009 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate the essential role of epithelial-derived Act1 in allergic pulmonary inflammation through the distinct impact of the IL-17R-Act1 and IL-25R-Act1 axes.
|
19155512 |
2009 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together with the act1 chromosome localization at the 6q21 subregion, our findings indicate that the newly identified alternatively spliced Act1 is a major transcript of the molecule and that Act1 may play important roles in oncogenesis.
|
12163033 |
2002 |