|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
BEFREE |
Collectively, these results implicate NETs and the Act1 D10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases.
|
30528823 |
2019 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
BEFREE |
Collectively, these results implicate NETs and the Act1 D</span>10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases.
|
30528823 |
2019 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
BEFREE |
We have replicated the association of TRAF3IP2-_rs33980500 variant with the susceptibility to psoriasis.
|
24005976 |
2014 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
BEFREE |
The hyperactive Th17 response combined with fully responsive fibroblasts likely synergized to contribute to psoriasis susceptibility in SNP-D10N patients.
|
25024377 |
2014 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
BEFREE |
By contrast, healthy individuals homozygous for the common variant D10N, located in the ACT1 tumor necrosis factor receptor-associated factor-interacting domain and previously associated with psoriasis, had impaired, but not abolished, responses to IL-17 cytokines.
|
24120361 |
2013 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
BEFREE |
In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility.
|
23202271 |
2013 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
T |
0.850 |
GeneticVariation |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.850 |
GeneticVariation |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
T |
0.850 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
T |
0.850 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation |
BEFREE |
However, the dominant PsA-associated TRAF3IP2 (Act1) gene single-nucleotide polymorphism (rs33980500) results in decreased binding of Act1 to TRAF6.
|
23116200 |
2012 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
T |
0.820 |
GeneticVariation |
GWASDB |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation |
BEFREE |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
rs397518485
|
TRAF3IP2;TRAF3IP2-AS1
|
CANDIDIASIS, FAMILIAL, 8
|
|
0.800 |
GeneticVariation |
UNIPROT |
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
|
24120361 |
2013 |
|
rs397518485
|
TRAF3IP2;TRAF3IP2-AS1
|
CANDIDIASIS, FAMILIAL, 8
|
A |
0.800 |
CausalMutation |
CLINVAR |
|
|
|
|
rs13190932
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
|
0.710 |
GeneticVariation |
GWASCAT |
Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.
|
30552173 |
2019 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis vulgaris
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
rs13190932
|
TRAF3IP2;TRAF3IP2-AS1
|
Arthritis, Psoriatic
|
|
0.710 |
GeneticVariation |
BEFREE |
We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10⁻¹⁷).
|
20953186 |
2010 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis vulgaris
|
|
0.710 |
GeneticVariation |
BEFREE |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
rs2179070
|
TRAF3IP2;TRAF3IP2-AS1
|
Inflammatory Bowel Diseases
|
|
0.700 |
GeneticVariation |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
rs7769061
|
TRAF3IP2
|
Psoriasis
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
|
25903422 |
2015 |
|
rs13210247
|
TRAF3IP2;TRAF3IP2-AS1
|
Psoriasis
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
rs33980500
|
TRAF3IP2;TRAF3IP2-AS1
|
PSORIASIS 13, SUSCEPTIBILITY TO
|
|
0.700 |
GeneticVariation |
UNIPROT |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |