|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.
|
30552173 |
2019 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and psoriatic arthritis.
|
25775161 |
2015 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
TRAF3IP2 gene, associated with susceptibility to psoriatic arthritis and psoriasis, encodes for Act1, a negative regulator of adaptive immunity and a positive signaling adaptor in IL-17-mediated immune responses.
|
23836313 |
2013 |
|
Arthritis, Psoriatic
|
0.470 |
Biomarker
|
disease |
BEFREE |
The recent observations described and discussed in this review raise the clinically significant possibility of redefining the immunological role of IL-17 in PsA and provide a basis for defining future studies to elucidate the molecular and cellular functions of Act1.
|
23116200 |
2012 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization.
|
22513239 |
2012 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Only three modestly sized genome-wide association studies of PsA have been undertaken to date, but they have identified the HLA-C region, IL12B, TRAF3IP2, and FBXL19 genes as being associated with PsA susceptibility.
|
22532288 |
2012 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.
|
20953186 |
2010 |
|
Arthritis, Psoriatic
|
0.470 |
Biomarker
|
disease |
CTD_human |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.
|
20953186 |
2010 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.
|
20953186 |
2010 |
|
Arthritis, Psoriatic
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
Arthritis, Psoriatic
|
0.470 |
Biomarker
|
disease |
CTD_human |
Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.
|
20953186 |
2010 |