|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In an orthotopic implantation model using mice, administration of nestin siRNA significantly decreased primary and metastatic tumor formation by human pancreatic cancer cells compared to tumor formation in control siRNA-treated mice.
|
26335012 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Positive nestin immunostaining was most obviously detected in the cytoplasm, nucleus or both cytoplasm and nucleus of tumor cells in 19.2% (24/125) of GAC tissues, which was significantly higher than that in normal gastric mucosa tissues (1.7%, 1/60) (p=0.001).
|
25854362 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, higher rates of nestin expression were observed in most embryonal RMS specimens and low-grade tumors, in early stages of the disease, and among younger patients.
|
26600525 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Altogether, these results suggest that GFAP-δ and nestin could be clinically relevant markers associated with tumor invasiveness in cerebral astrocytomas.
|
25178519 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, compared with control cells, nestin short hairpin RNA (shRNA)-transfected glioblastoma cells exhibited reduced sphere formation, decreased expression of NANOG, N-cadherin, CD133, and Oct-4, and decreased tumor size in vivo.
|
25527454 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Likewise, depletion of Nestin inhibits tumor cell proliferation, arrest cells at G2/M, induces apoptosis and suppresses xenograft tumor formation in vivo.
|
25118937 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin immunoreactivity significantly correlated with not only tumor size and lymph node metastasis in NSCLC, but also poor survival in surgical patients with AD.
|
24481417 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conversely, knockdown of nestin expression led to significant inhibition of tumor cell proliferation, decreased colony forming ability, and cell cycle G1 arrest.
|
24498263 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this report, we describe tumor stem cell (TSC) marker CD133, CD15 and nestin alterations in ETANTR before and after chemotherapy.
|
23865520 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Surprisingly, we recently confirmed NES as a tumour-specific marker for mature CD138(+) 38(+) plasma cells (PC) in multiple myeloma (MM).
|
24329895 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression was also studied immunohistochemically in surgically resected SCLC primary tumors and metastatic SCLC tumors obtained from autopsy cases.
|
23706418 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin may be an important marker of melanocytic neoplasms.
|
23417116 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression occurs in approximately one third of pancreatic ductal adenocarcinoma (PDAC), and its expression strongly correlates with tumor staging and metastasis.
|
23552743 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis.
|
22246533 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Neuropathological studies, assayed by immunohistochemical staining, showed that the tumor sample was positive to antibodies against S-100, CgA, AE1/AE3 (cytokeratin), Ki-67, INI1 and TP53, and was negative to antibodies against Nestin, GFAP, CD133, EMA and AFP.
|
22534715 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that nestin plays important roles in carcinogenesis and tumor formation of cervical cancer cells.
|
22580387 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression in tumor cells was immunohistochemically studied in 30 patients with resected LCNEC, and its associations with clinicopathologic parameters including the Ki-67 labeling index (LI) and TTF-1 expression were evaluated.
|
22572237 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin-positive tumor cells were detected in all of the examined osteosarcomas using both immunohistochemistry and immunofluorescence, although the proportion of undoubtedly positive neoplastic cells varied in individual samples from a few nestin-positive tumor cells to diffuse nestin positivity.
|
22344865 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings indicate that nestin may be a marker for newly synthesized tumor vessels and a therapeutic target for tumor angiogenesis.
|
21274370 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms.
|
22297445 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, C6 subclones that expressed nestin at low levels in vitro were also found to give rise to tumors highly positive for the protein, suggesting that induction of nestin plays an important role in glioblastoma carcinogenesis.
|
20669222 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In surgical specimens of human glioma, tumor vascular cells coexpressing the markers of early VECs (CD34) and markers of hGSPCs (ABCG2 and nestin) suggest that these vascular cells may stemmed from hGSPCs.
|
20697979 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD133 and nestin were detected in all 10 tumor tissue samples and in all 5 cell lines; however, the frequency of CD133+, Nes+, and CD133+/Nes+ cells, as well as the intensity of fluorescence varied in individual samples or cell lines.
|
22156015 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival.
|
21323603 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conditional expression of SCCRO using a replication-competent ASLV long terminal repeat with splice acceptor/nestin-(tumor virus-A) tv-a model system was not sufficient to induce tumor formation in a wild-type genetic background, but tumors formed with increasing frequency and decreasing latency in facilitated background containing Ink4a deletion alone or in combination with PTEN loss.
|
20563250 |
2010 |