|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the combination therapy decreased the expression of the glioma stem-like cell markers CD133 and Nestin and compromised glioma stem-like cell self-renewal capabilities.
|
31241171 |
2020 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of miR-487b in a pediatric glioma cell line (KNS42) using lentiviral vectors led to a decrease in colony formation in soft agar (30%) (P<0.05), and decreased expression of known predicted targets PROM1 and Nestin (but not WNT5A). miR-487b overexpression had no significant effect on cell growth, proliferation, sensitivity to temozolomide, migration, or invasion.
|
27739438 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results showed that nestin protein abundance was significantly correlated with the histological grade [odds ratio (OR) = 4.36, 95 % confidence interval (CI) = 2.14-8.88, P = 0.003] of glioma.
|
26768429 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we aimed to evaluate the association between the expression of CD133 and Nestin and the outcome of glioma patients by conducting a systematic review and meta-analysis.
|
25967234 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a spontaneous mouse model of glioma, ectopic expression of the IE1 gene (UL123) specifically increased Sox2 and Nestin levels in the IE1-positive tumors, upregulating stemness and proliferation markers in vivo.
|
26239477 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that Nestin (a type VI intermediate filament protein), like the glioma stem cell (GSC) markers CD133 and CD15, exhibited different levels of expression in primary human glioblastoma specimens.
|
23524267 |
2013 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, blockade of JNK signaling with SP600125 or small interfering RNAs targeting JNK1 or JNK2 significantly reduced the CD133(+)/Nestin(+) population and suppressed sphere formation, colony formation in soft agar, and expression of stem cell markers in sphere-cultured glioma cells.
|
22249269 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An RFP-expressing glioma was transplanted to the spinal cord of transgenic nude mice expressing nestin-driven green fluorescent protein (ND-GFP).
|
21347627 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, unspecific markers (ABCG2, nestin) that stain for both endothelial as well as glioma stem cells, were found to be expressed in tumor vasculature of human specimen, and limit further interpretation of this finding.
|
20697979 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, overexpression of TLX in Ink4a/Arf(-/-) astrocytes inhibited cell migration and invasion and promoted neurosphere formation and Nestin expression, which are hallmark characteristics of glioma stem cells, under stem cell culture conditions.
|
20814749 |
2010 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis with anti-Nestin and anti-CD133 antibodies revealed dense and spotty staining in the tumor cells and their expression levels became significantly higher as the glioma grade advanced (p < 0.05).
|
19108713 |
2008 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nestin is shown to be a strong prognostic marker for glioma malignancy.
|
17537489 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In a series of 40 surgical specimens, including gliomas, vascular malformations, abscesses and angiomas, the glial reaction has been studied by immunohistochemistry and immunofluorescence of Nestin, GFAP and Vimentin.
|
16826367 |
2006 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of nestin mRNA was confirmed in 6 of 6 human glioma lines and in 3 of 4 primary glioma cells.Normal human astrocytes were negative.
|
15805284 |
2005 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, many tumors were negative for nestin immunostaining, while nestin immunostaining was invariably detected in tumor endothelium regardless of glioma malignancy grades or brain tumor types.
|
11896213 |
2002 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioma/glioblastoma-specific adenoviral gene expression using the nestin gene regulator.
|
10800092 |
2000 |