CFTR, CF transmembrane conductance regulator, 1080

N. diseases: 476; N. variants: 673
Disease: Paranasal Sinus Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030469
Disease: Paranasal Sinus Disorder
Paranasal Sinus Disorder 		0.040 GeneticVariation group BEFREE Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease. 30152192 2019
CUI: C0030469
Disease: Paranasal Sinus Disorder
Paranasal Sinus Disorder 		0.040 Biomarker group BEFREE Characterization of primary rat nasal epithelial cultures in CFTR knockout rats as a model for CF sinus disease. 28771736 2017
CUI: C0030469
Disease: Paranasal Sinus Disorder
Paranasal Sinus Disorder 		0.040 AlteredExpression group BEFREE The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on primary sinus epithelial cultures. 25363320 2015
CUI: C0030469
Disease: Paranasal Sinus Disorder
Paranasal Sinus Disorder 		0.040 Biomarker group BEFREE Septal PNE exhibit a robust ion transport phenotype and indicate CFTR(-/-) sinus disease could be attributable to diminished alternative pathways for Cl(-) transport. 24733748 2014