CFTR, CF transmembrane conductance regulator, 1080

N. diseases: 476; N. variants: 673
Disease: Respiratory Tract Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035242
Disease: Respiratory Tract Diseases
Respiratory Tract Diseases 		0.020 Biomarker group BEFREE Both mechanisms fail in CFTR<sup>-/-</sup> swine, suggesting that cystic fibrosis airways do not respond to inhaled pathogens, thus favoring infection and inflammation that may eventually lead to tissue remodeling and respiratory disease.Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. 28983075 2017
CUI: C0035242
Disease: Respiratory Tract Diseases
Respiratory Tract Diseases 		0.020 Biomarker group BEFREE We also report on initial experiments in which CFTR(-/-) mice have been exposed to bacterial pathogens, and we present data on a single animal that displayed severe respiratory disease. 7533607 1995