Pancreatitis, Chronic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
While CFTR modulation has been shown to alkalinize the pH of the alimentary tract and potentially augment pancreatic enzyme activity, the effect of ivacaftor on recurrent pancreatitis is emerging.
|
31296159 |
2019 |
Pancreatitis, Chronic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Complete diagnostic testing for CFTR-RD in patients with ARP/CP will broaden treatment options and help to identify comorbid illness.
|
31268981 |
2019 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Having a variant from CFTR, SPINK1 or PRSS1, was associated with the faster progression from AP to CP over time (p < 0.05).
|
31088717 |
2019 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis.
|
30420730 |
2018 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We compared outcomes after TPIAT for CP associated with CFTR mutations to CP without CTFR mutations.
|
29206667 |
2018 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
F508 deletion in CFTR was significantly positively associated with CP risk in the overall analysis (odds ratio [OR]=3.20, 95% CI: 2.30-4.44, I<sup>2</sup>=31.7%).
|
28780053 |
2017 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relationship between CFTR and CTRC variants and the clinical phenotype in late-onset cystic fibrosis disease with chronic pancreatitis.
|
25636364 |
2015 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Whole exome sequencing analysis detected one novel disruptive frameshift mutation in the ASXL1 gene and we were also able to confirm the presence of two CFTR mutations associated with her chronic pancreatitis with acute severe breakthrough attacks requiring multiple ICU admissions.
|
26364555 |
2015 |
Pancreatitis, Chronic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We measured CFTR levels and localization in pancreatic tissues and in patients with acute or chronic pancreatitis induced by alcohol.
|
25447846 |
2015 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Exon sequences of the CFTR gene from 193 patients with chronic pancreatitis (121 idiopathic, 46 alcoholic, 17 hereditary, and nine familial) were captured by HaloPlex target enrichment technology, followed by NGS.
|
25492507 |
2015 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have investigated the association of CFTR variants and chronic pancreatitis in Japanese and the functional characteristics of a Japanese- and pancreatitis-specific CFTR variant, L1156F.
|
26089335 |
2015 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Spectrum and distribution of CFTR gene mutations in asthma and chronic pancreatitis cases of North Indian population.
|
24440239 |
2014 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the cationic trypsinogen (PRSS1), cystic fibrosis transmembrane conductance regulator (CFTR), serine protease inhibitor Kazal type 1 (SPINK1), and chymotrypsin C (CTRC) genes are associated with an elevated risk for chronic pancreatitis, which is a known risk factor for pancreatic cancer (PC).
|
25003218 |
2014 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, the study demonstrates the complexity of genetic interactions in CP and a minor influence of CFTR alterations in CP development.
|
22427236 |
2013 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in three genes, the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene and the pancreatic secretory trypsin inhibitor (SPINK1) gene, have been identified as risk factors for CP.
|
22109105 |
2012 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We screened patients and controls for variants in SPINK1 associated with risk of chronic pancreatitis and in all 27 exons of CFTR.
|
20977904 |
2011 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A novel exon duplication of the cystic fibrosis transmembrane conductance regulator in a patient presenting with adult-onset recurrent pancreatitis.
|
21673536 |
2011 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens.
|
21520337 |
2011 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Independent contribution of common CFTR variants to chronic pancreatitis.
|
19812525 |
2010 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several genetic mutations, specifically, PRSS1, CFTR, and SPINK1, are associated with chronic pancreatitis.
|
20846557 |
2010 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thirty-three CFTR mutations were analyzed in CP and ARP patients using multiplex DNA testing.
|
19844201 |
2010 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Impact of cystic fibrosis transmembrane conductance regulator gene mutation on the occurrence of chronic pancreatitis in Japanese patients.
|
19383231 |
2009 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CFTR polymorphisms in patients with alcoholic chronic pancreatitis.
|
19077469 |
2009 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function variants in the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-sensing receptor (CASR) genes also increase the risk of CP.
|
19453252 |
2009 |
Pancreatitis, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cystic fibrosis transmembrane conductance regulator (CFTR), cationic trypsinogen gene (PRSS1), and serine protease inhibitor kazal type 1 (SPINK1) gene mutations have been associated with chronic pancreatitis (CP).
|
18953248 |
2008 |