CCR9, C-C motif chemokine receptor 9, 10803

N. diseases: 90; N. variants: 1
Disease: Ulcerative Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.040 Biomarker disease BEFREE Antagonism of CCR9 is a promising mechanism for treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. 29582229 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.040 Biomarker disease BEFREE The aim of this first-in-human, double-blind, randomised, placebo-controlled trial was to evaluate selective removal of circulating CCR9-expressing monocytes by leukapheresis in patients with moderate to severe ulcerative colitis, with regards to safety, tolerability, and immunological response. 28453759 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.040 Biomarker disease BEFREE These findings indicate that the CCR9:CCL25 pair plays a causative role in ulcerative colitis and suggest that CCR9 antagonists will provide a therapeutic benefit in patients with colonic inflammation. 26457007 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.040 AlteredExpression disease BEFREE NKT receptor CD161, CCL25 and CCR9 expression levels were significantly increased in UC patients. 24936795 2014