HPSE, heparanase, 10855

N. diseases: 393; N. variants: 12
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE A multifactorial analysis using Cox's regression model revealed that β-catenin, lymphoid enhancer-binding protein-1, heparanase-1, and the TNM stage were all independent factors in malignant melanoma (risk ratios were 7.294, 5.550, 5.622, and 4.794; p-values were 0.007, 0.018, 0.018, and 0.029, respectively). 25343173 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Therefore, we investigated the relevance of the dual functions of HPSE to malignant melanoma in vitro, as well as in different mouse melanoma models based on the intradermal or intravenous injection of melanoma cells. 25745999 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity. 23847439 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease CTD_human Heparanase DNA vaccine delivered by electroporation induces humoral immunity and cytoimmunity in animal models. 22240343 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation. 22719918 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Therefore, VEGF likely has a potential function as a regulator of heparanase expression in melanoma. 21624769 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease LHGDN Atypical melanocytes and melanoma cells expressed heparanase, VEGF and VEGFR-2. 18288398 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease LHGDN Heparanase mechanisms of melanoma metastasis to the brain: Development and use of a brain slice model. 16288472 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease LHGDN Elevated HPSE expression contributes to melanoma progression; however, further augmentation of HPSE presence can inhibit tumorigenicity. 16867222 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Our results suggest that HPSE-1 not only contributes to the invasive phenotype of melanoma cells, but also that the Ad-AS/hep-mediated inhibition of its enzymatic activity can be efficacious in the prevention and treatment of melanoma metastasis. 15799825 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease LHGDN Our results provide evidence demonstrating that HPSE-1 likely plays important roles in regulating the in vivo growth and progression of melanoma. 15645118 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease LHGDN Restoration of HPSE-1 expression and functionality following Ad-S/hep infection of KCREB-transfected 70W cells recovered melanoma cell invasiveness. 15368349 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Restoration of HPSE-1 expression and functionality following Ad-S/hep infection of KCREB-transfected 70W cells recovered melanoma cell invasiveness. 15368349 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE The heparanase mRNA and protein are preferentially expressed in metastatic cell lines and in specimens of human melanomas and carcinomas. 10909416 2000
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Low metastatic murine T-lymphoma and melanoma cells transfected with the heparanase cDNA acquired a highly metastatic phenotype in vivo, reflected by a massive liver and lung colonization. 10395325 1999