|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.
|
29662167 |
2018 |
|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
CTD_human |
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.
|
29662167 |
2018 |
|
Prostatic Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
The results of this study provide important insights into the role of metalloproteinases in human prostate cancer.The expression of ADAM28 protein levels was assessed within human prostate tumors and normal adjacent tissue by immunohistochemistry.
|
27749584 |
2016 |
|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
BEFREE |
This study supports the notion that inhibition of ADAM28 may be a potential novel therapeutic strategy for human prostate cancer.
|
27749584 |
2016 |
|
Malignant neoplasm of lung
|
0.310 |
Biomarker
|
disease |
BEFREE |
Serum levels of a disintegrin and metalloproteinase (ADAM)-8 and ADAM-28 are higher in lung cancer patients than in healthy controls.
|
22292754 |
2012 |
|
Malignant neoplasm of lung
|
0.310 |
Biomarker
|
disease |
CTD_human |
ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas.
|
20544843 |
2010 |
|
Lung Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas.
|
20544843 |
2010 |
|
Stage IV Skin Melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
The analysis showed that serum levels of ADAM10 and ADAM28 are significantly higher in patients with colorectal cancer and correlate with histopathological grading and with presence of distant metastases.
|
31565100 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
ADAM28 (a disintegrin and metalloproteinase 28) is abundantly expressed by carcinoma cells in the human breast and non-small cell lung carcinomas, and plays a role in carcinoma cell growth and metastasis.
|
29882245 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis.
|
30190423 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Our data highlight a functional role of ADAM28 in T cell mobilization and point to an unexpected protective role for host ADAM28 against metastasis.
|
30647853 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
These results suggested that miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28, which may be a novel target for CRC treatment and warrants for further investigation.
|
27661126 |
2016 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
We explored the mechanism of ADAM28-mediated metastasis by searching for new substrates of ADAM28.
|
22636800 |
2012 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
High expression of ADAM-28 correlates with metastasis and recurrence, but there is no significant difference in ADAM-8 or ADAM-28 expression between AD and SQ.
|
22292754 |
2012 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The ADAM28 and its co-expressed genes were analyzed in the cBioPortal for cancer genomics and subjected to GSEA pathway analysis.
|
31602160 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway.
|
30840270 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The analysis showed that serum levels of ADAM10 and ADAM28 are significantly higher in patients with colorectal cancer and correlate with histopathological grading and with presence of distant metastases.
|
31565100 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The ADAM28 and its co-expressed genes were analyzed in the cBioPortal for cancer genomics and subjected to GSEA pathway analysis.
|
31602160 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
However, the role of host-derived ADAM28 in cancer dissemination processes remains unclear.
|
30647853 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
ADAM28 (a disintegrin and metalloproteinase 28) is overexpressed by carcinoma cells in non-small cell lung carcinomas (NSCLC) and plays an important role in cancer cell proliferation and metastasis by reactivation of insulin-like growth factor-1 (IGF-1) and escaping from von Willebrand factor (VWF)-induced apoptosis through digestion of IGF-binding protein-3 and VWF, respectively.
|
30190423 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ADAM28 (a disintegrin and metalloproteinase 28) is abundantly expressed by carcinoma cells in the human breast and non-small cell lung carcinomas, and plays a role in carcinoma cell growth and metastasis.
|
29882245 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that antibody 211-14 is a neutralizing antibody specific to ADAM28s and suggest that this antibody may be a useful treatment remedy for NSCLC patients.<i></i>.
|
30190423 |
2018 |
|
Carcinoma of lung
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of SOX4 promoted the ADAM28 gene expression and migration in human breast and lung carcinoma cell lines.
|
29882245 |
2018 |
|
Carcinoma of lung
|
0.040 |
Biomarker
|
disease |
BEFREE |
Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis.
|
30190423 |
2018 |