|
Obesity
|
0.300 |
Therapeutic
|
disease |
RGD |
Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers.
|
23256146 |
2013 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Mice lacking SHP show increased basal expression of PGC-1alpha, increased energy expenditure, and resistance to diet-induced obesity.
|
16213225 |
2005 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.
|
30570131 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent studies report that PGC-1α-null mice develop late-onset obesity and that the neuronal inactivation of PGC-1α causes increased food intake.
|
22016516 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, the transcript and protein levels of transcriptional coactivator peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) and estrogen-related receptor-α (ERRα) in DIO-R mice were significantly up-regulated compared with the DIO mice.
|
28444662 |
2017 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed.
|
26185753 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We confirm the role of PPARGC1A in muscle and show some support for inflammation in adipose from European American subjects but find prominent roles for lipid metabolism in insulin sensitivity independent of obesity in both tissues.
|
21266331 |
2011 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
|
27473963 |
2016 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study aims to test whether 10 polymorphisms in obesity-related genes methionine sulfoxide reductase A (MSRA), transcription factor AP-2 beta (TFAP2B), melanocortin 4 receptor (MC4R), neurexin 3 (NRXN3), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), transmembrane protein 18 (TMEM18), homolog of S. cerevisiae Sec16 (SEC16B), homeobox B5 (HOXB5) and olfactomedin 4 (OLFM4) are associated with the risk of obesity in Portuguese children.
|
24670271 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma coactivator-1alpha (PGC-1alpha) system plays an important role in the regulation of efficient energy utilization and oxidative phosphorylation, both of which are decreased in obesity and insulin resistance.
|
19966034 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity.
|
22401878 |
2012 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals.
|
12565902 |
2003 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men.
|
16474966 |
2006 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We tested whether a targeted reduction in hepatic peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which has been shown to occur with obesity, had a negative impact on the metabolic effects of FGF21.
|
29215172 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Two strong positional candidates, the human peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1) and cholecystokinin A receptor (CCKAR) with major roles in the development of obesity, are located in this region.
|
14740316 |
2004 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review, we outline the function of PGC-1 coactivators in physiological and pathological conditions as well as the complex interplay of metabolic dysregulation and inflammation in obesity with special focus on skeletal muscle.
|
24258516 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to determine the possible association of five single-nucleotide polymorphisms (SNPs) located in the IGF2, LEPR, POMC, PPARG, and PPARGC1 genes with obesity or obesity-related risk phenotypes.
|
25923461 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction.
|
19077249 |
2008 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population.
|
25928419 |
2015 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
BACE1 expression was increased in subcutaneous adipose tissue of obese and type 2 diabetic patients and this was accompanied by a decrease in PGC-1α mRNA levels and by an increase in sAPPβ plasma levels of obese type 2 diabetic patients compared to obese non-diabetic subjects.
|
29526536 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
PGC-1α has been implicated in the pathogenic conditions including obesity, type 2 diabetes, neurodegeneration, and cardiomyopathy, whereas PGC-1β plays an important role in plasma lipoprotein homeostasis and serves as a hepatic target for niacin, a potent hypotriglyceridemic drug.
|
21325336 |
2011 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Special emphasis is placed on the effects of high fat diet (HFD) feeding on expression of nuclear-encoded mitochondrial genes (NEMGs) nuclear receptor factor 1 (NRF-1) and 2 (NRF-2) and peroxisome proliferator receptor gamma coactivator 1 alpha (PGC-1α) in the onset and progression of insulin resistance during obesity and how HFD-induced alterations in NEMG expression affect skeletal muscle mitochondrial adaptations in relation to beta oxidation of fatty acids.
|
28420087 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These studies suggest functional differences of PPARGC1 haplotypes in human energy metabolism and support a role of PPARGC1 in obesity.
|
11916956 |
2002 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The current study is the first to provide evidence that Met could ameliorate muscle atrophy in high-fat diet induced obesity and this effect may be in part due to regulation of PGC-1α-FoxO3 pathway.
|
30320911 |
2019 |