|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
PGC-1α has been implicated in the pathogenic conditions including obesity, type 2 diabetes, neurodegeneration, and cardiomyopathy, whereas PGC-1β plays an important role in plasma lipoprotein homeostasis and serves as a hepatic target for niacin, a potent hypotriglyceridemic drug.
|
21325336 |
2011 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed.
|
26185753 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although primarily investigated for its therapeutic potential in obesity and skeletal muscle differentiation, the ability of PGC-1α to alter a multitude of cellular functions has sparked interest in its role in the vasculature.
|
27312223 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
An interaction between ERRα and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) has also recently been shown to regulate an enzyme in the β-oxidation of free fatty acids, thereby suggesting that ERRα plays an important role in obesity and type 2 diabetes.
|
29216352 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
At least in the subcutaneous fat of humans and mice the levels of PGC-1α decrease during obesity, while its physical association with A20 increases.
|
29678181 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
BACE1 expression was increased in subcutaneous adipose tissue of obese and type 2 diabetic patients and this was accompanied by a decrease in PGC-1α mRNA levels and by an increase in sAPPβ plasma levels of obese type 2 diabetic patients compared to obese non-diabetic subjects.
|
29526536 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, the transcript and protein levels of transcriptional coactivator peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) and estrogen-related receptor-α (ERRα) in DIO-R mice were significantly up-regulated compared with the DIO mice.
|
28444662 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, DBT could stimulate phosphorylation of AMPK to raise expression of UCP1 and PGC-1α, and activate thermogenesis to prevent obesity.
|
30258363 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review, we outline the function of PGC-1 coactivators in physiological and pathological conditions as well as the complex interplay of metabolic dysregulation and inflammation in obesity with special focus on skeletal muscle.
|
24258516 |
2014 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men.
|
16474966 |
2006 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Mice lacking SHP show increased basal expression of PGC-1alpha, increased energy expenditure, and resistance to diet-induced obesity.
|
16213225 |
2005 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.
|
30570131 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent studies report that PGC-1α-null mice develop late-onset obesity and that the neuronal inactivation of PGC-1α causes increased food intake.
|
22016516 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity.
|
22401878 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Special emphasis is placed on the effects of high fat diet (HFD) feeding on expression of nuclear-encoded mitochondrial genes (NEMGs) nuclear receptor factor 1 (NRF-1) and 2 (NRF-2) and peroxisome proliferator receptor gamma coactivator 1 alpha (PGC-1α) in the onset and progression of insulin resistance during obesity and how HFD-induced alterations in NEMG expression affect skeletal muscle mitochondrial adaptations in relation to beta oxidation of fatty acids.
|
28420087 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies in mice have shown that increased PGC-1α expression may be beneficial or deleterious, depending on the tissue: in adipose tissue, it promotes thermogenesis and thus protects against energy overload, such as seen in diabetes and obesity; in muscle, PGC-1α induces a change of phenotype towards oxidative metabolism.
|
25753246 |
2015 |
|
Obesity
|
0.300 |
Therapeutic
|
disease |
RGD |
Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers.
|
23256146 |
2013 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction.
|
19077249 |
2008 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to determine the possible association of five single-nucleotide polymorphisms (SNPs) located in the IGF2, LEPR, POMC, PPARG, and PPARGC1 genes with obesity or obesity-related risk phenotypes.
|
25923461 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population.
|
25928419 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The current study is the first to provide evidence that Met could ameliorate muscle atrophy in high-fat diet induced obesity and this effect may be in part due to regulation of PGC-1α-FoxO3 pathway.
|
30320911 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma coactivator-1alpha (PGC-1alpha) system plays an important role in the regulation of efficient energy utilization and oxidative phosphorylation, both of which are decreased in obesity and insulin resistance.
|
19966034 |
2010 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
|
27473963 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These studies suggest functional differences of PPARGC1 haplotypes in human energy metabolism and support a role of PPARGC1 in obesity.
|
11916956 |
2002 |