We selected the <i>PPARG</i> rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between <i>PPARG, PPARGC1A, PPARGC1B</i> their variants and risk of CRC.
In this review, we provide an overview of the literature dealing with the main coactivators (NCoA-1 to 3, NCoA-6, PGC1-α, p300, CREBBP and MED1) and corepressors (N-CoR1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.
In conclusion, the results of this study suggest that a pro-inflammatory diet may have a differential effect on colorectal cancer risk based on PPARGC1A genetic variation.