|
IMMUNODEFICIENCY 12
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.
|
25627829 |
2015 |
|
IMMUNODEFICIENCY 12
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Combined immunodeficiency associated with homozygous MALT1 mutations.
|
24332264 |
2014 |
|
IMMUNODEFICIENCY 12
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.
|
23727036 |
2013 |
|
IMMUNODEFICIENCY 12
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.
|
23727036 |
2013 |
|
IMMUNODEFICIENCY 12
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
IMMUNODEFICIENCY 12
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that the expression of the paracaspase mucosa-associated lymphoid tissue l (MALT1), a protease previously linked to antigen receptor-mediated NF-κB activation and B-cell lymphoma survival, inversely correlates with patient probability of survival.
|
31774199 |
2020 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mucosa-associated lymphoid tissue lymphoma translocation 1 protein (MALT1) consisting of death domain, Ig-like domains and caspase-like domain is expressed in nucleus of oral carcinoma cells, and loss of the expression closely associates with disease progression and stimulates proliferation of the cells.
|
31791579 |
2020 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study tested the hypothesis that mucosa associated lymphoid tissue 1 (Malt1) deficiency causes osteoporosis in mice by increasing osteoclastogenesis and osteoclast activity.
|
31313375 |
2019 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Following activation of CD4<sup>+</sup> T cells, however, N4BP1 undergoes rapid cleavage at Arg 509 by the paracaspase named mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1).
|
31133753 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aggressive activated B-cell like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) exploits a multi-protein complex of CARMA1, BCL10, and MALT1 (CBM complex), which normally conveys NF-κB signaling upon antigen receptors engagement.
|
30474008 |
2018 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study confirms that genes involved in activation of NF-κB-signaling pathways are a major driver in oncogenesis of H. pylori eradication-resistant gastric marginal zone lymphoma and revealed that TRAF3 mutation is a major contributor in MALT1 rearrangement-negative gastric marginal zone lymphoma.
|
29765142 |
2018 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflammatory responses and was associated with restoration of healthy intestinal microbiome in mice suffering from dextran sulfate sodium (DSS)-induced colitis.
|
30249750 |
2018 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function.
|
30025160 |
2018 |
|
Diffuse Large B-Cell Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The biological significance of BAFF signalling in t(11;18)(q21;q21)-negative lymphoma cells was further studied in two types of lymphoma B cell: OCI-Ly3 [non-germinal centre B-cell origin DLBCL without t(11;18)(q21;q21) cell line] and MA-1 [t(14;18)(q32;q21)/IGH-MALT1-positive DLBCL cell line].
|
27873317 |
2017 |
|
Diffuse Large B-Cell Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization detected IGH/BCL2 translocation in 1 FL, increased BCL6 copy number in another FL, BCL6 rearrangement, and increased copy number of MYC and MALT1 in the DLBCL with marginal zone lymphoma.
|
28038709 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified a homozygous missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1), which precluded protein expression.
|
27253662 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To identify the clinical features of gastric mucosa-associated lymphoid tissue (MALT) lymphoma with extra copies of MALT1.
|
28970731 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood.
|
28928392 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The three translocations seen in MALT lymphoma, namely t(14;18)(q32;q21)/IGH-MALT1, t(1;14)(p22;q32)/BCL10-IGH, and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1 are capable of activating both canonical and non-canonical NF-κB pathways.
|
28288707 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regnase-1 activation is transient and is subject to negative feedback mechanisms including proteasome-mediated degradation or mucosa-associated lymphoid tissue 1 (MALT1) mediated cleavage.
|
28194024 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mucosa-associated lymphoma antigen 1 (MALT1) is a lymphoma oncogene that regulates signal transduction as a paracaspase and an adaptor protein.
|
28759024 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization detected IGH/BCL2 translocation in 1 FL, increased BCL6 copy number in another FL, BCL6 rearrangement, and increased copy number of MYC and MALT1 in the DLBCL with marginal zone lymphoma.
|
28038709 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Luciferase assays revealed that ebv-miR-BHRF1-2-5p may directly target MALT1 (mucosa-associated lymphoid tissue lymphoma transport protein 1), a key regulator of immune homeostasis.
|
28253538 |
2017 |
|
Diffuse Large B-Cell Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth and apoptosis of the DLBCL cell line OCI-LY1, and their associations with A20, MALT1 and survivin levels.
|
27349720 |
2016 |