|
Obesity
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
|
29311636 |
2018 |
|
Obesity
|
0.490 |
Biomarker
|
disease |
BEFREE |
This locus has provided novel biological insights, as it has been shown that reduced ADCY3 function causes obesity through disrupted function in primary cilia.
|
30101502 |
2018 |
|
Obesity
|
0.490 |
Biomarker
|
disease |
BEFREE |
These findings highlight ADCY3 as an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity.
|
29311637 |
2018 |
|
Obesity
|
0.490 |
Biomarker
|
disease |
CTD_human |
We demonstrate that MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons, that obesity-associated MC4R mutations impair ciliary localization and that inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight.
|
29311635 |
2018 |
|
Obesity
|
0.490 |
Biomarker
|
disease |
BEFREE |
Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity.
|
29454745 |
2018 |
|
Obesity
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
|
29311635 |
2018 |
|
Obesity
|
0.490 |
Biomarker
|
disease |
BEFREE |
We performed a 2 × 2 factorial experiment to study the relationships among AC3, liraglutide and obesity and to obtain a more comprehensive understanding of the mechanisms underlying the physiological effects of liraglutide on obesity.
|
28481334 |
2017 |
|
Obesity
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
In this review, we describe genomic and biological features of ADCY3, summarize genetic and epigenetic association studies of the ADCY3 gene with obesity and discuss dysfunction and activation of ADCY3.
|
27256589 |
2016 |
|
Obesity
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene.
|
21079816 |
2010 |
|
Obesity
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.
|
17895882 |
2008 |
|
Obesity
|
0.490 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity, Morbid
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Here we identify and functionally characterize homozygous mutations in the ADCY3 gene encoding adenylate cyclase 3 in children with severe obesity from consanguineous Pakistani families, as well as compound heterozygous mutations in a severely obese child of European-American descent.
|
29311637 |
2018 |
|
Obesity, Morbid
|
0.310 |
Biomarker
|
disease |
CTD_human |
Here we identify and functionally characterize homozygous mutations in the ADCY3 gene encoding adenylate cyclase 3 in children with severe obesity from consanguineous Pakistani families, as well as compound heterozygous mutations in a severely obese child of European-American descent.
|
29311637 |
2018 |
|
Diabetic Angiopathies
|
0.300 |
Biomarker
|
disease |
CTD_human |
Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
|
25381014 |
2015 |
|
Microangiopathy, Diabetic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
|
25381014 |
2015 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51).
|
21042317 |
2012 |
|
Mood Disorders
|
0.300 |
Biomarker
|
group |
PSYGENET |
Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51).
|
21042317 |
2012 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
Inflammatory Bowel Diseases
|
0.110 |
Biomarker
|
group |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
Inflammatory Bowel Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.110 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |