|
Endometriosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
|
Adenocarcinoma of large intestine
|
0.200 |
ModifyingMutation
|
disease |
RGD |
Normal-appearing rat colonic mucosa and azoxymethane (AOM)-induced colorectal adenocarcinoma tissue expressed a barely detectable amount of BRD8 protein, but aggressive colon tumors induced with AOM and dextran sodium sulfate expressed BRD8 at a significantly higher level, suggesting that BRD8 expression is associated with tumor progression toward advanced stages and may aid to gain growth advantage.
|
19787264 |
2009 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
These SMAPs attenuated mitogenic signaling and triggered apoptosis in KRAS-mutant lung cancer cells and inhibited tumor growth in murine models.
|
28504652 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The PHF1 (PHD finger protein 1) gene, from 6p21, is known to be rearranged in ESS in a promiscuous way inasmuch as it has been shown to recombine with JAZF1, EPC1, MEAF6, and now also with BRD8, in tumors of this type.
|
28758277 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In contrast, indirect inactivation of the adherens junction through conditional knockout of p120 in mice was recently linked to tumor formation, indicating that p120 can also function as a tumor suppressor.
|
23950111 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer.
|
12671892 |
2003 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
|
14610055 |
2003 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Potential roles of p120 as a tumor suppressor or metastasis promoter are discussed.
|
12492499 |
2002 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Expression of betaglycan and p120 in most GCT argues against the hypothesis, but does not exclude the possibility that low or absent expression of p120 might be significant in a subset of these tumors.
|
11889215 |
2002 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Previous reports from this laboratory have shown marked cytocidal effects of the ISIS-3466 antisense phosphorothioate oligodeoxynucleotide to the human nucleolar protein p120 on human cancer cell lines in vitro and inhibition of tumor growth in vivo in an i.p/i.p.LOX cell model (L. Perlaky et al.Anti-Cancer Drug Design 8:3-14, 1993).
|
8287366 |
1993 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The present study showed that increased miR-223 and decreased p120 levels are associated with colon cancer malignancy, and p120 expression is negatively correlated with miR-223 expression.
|
28969027 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
A SMAP in the face for cancer.
|
28504652 |
2017 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The present study showed that increased miR-223 and decreased p120 levels are associated with colon cancer malignancy, and p120 expression is negatively correlated with miR-223 expression.
|
28969027 |
2017 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
A SMAP in the face for cancer.
|
28504652 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Supporting these opposing functions are findings in human cancer, which show that either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.
|
23950111 |
2013 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Supporting these opposing functions are findings in human cancer, which show that either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.
|
23950111 |
2013 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
BRD8 is an accessory subunit of human NuA4-HAT (histone acetyl transferase) complex (also known as TRRAP/TIP60 complex), but its role in cancer and drug resistance is unknown.
|
19787264 |
2009 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
BRD8 is an accessory subunit of human NuA4-HAT (histone acetyl transferase) complex (also known as TRRAP/TIP60 complex), but its role in cancer and drug resistance is unknown.
|
19787264 |
2009 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Altered expression of the catenin p120 in human cancer: implications for tumor progression.
|
12492499 |
2002 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Altered expression of the catenin p120 in human cancer: implications for tumor progression.
|
12492499 |
2002 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Subsequent transfection of these transformed cells with a dexamethasone inducible antisense p120 construct (pMSG021) markedly reduced the expression of human p120 and the growth rate of these transformed cells (Perklaky et al., Cancer Res., (1992) 52, 428-436).
|
8443798 |
1993 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Previous reports from this laboratory have shown marked cytocidal effects of the ISIS-3466 antisense phosphorothioate oligodeoxynucleotide to the human nucleolar protein p120 on human cancer cell lines in vitro and inhibition of tumor growth in vivo in an i.p/i.p.LOX cell model (L. Perlaky et al.Anti-Cancer Drug Design 8:3-14, 1993).
|
8287366 |
1993 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Subsequent transfection of these transformed cells with a dexamethasone inducible antisense p120 construct (pMSG021) markedly reduced the expression of human p120 and the growth rate of these transformed cells (Perklaky et al., Cancer Res., (1992) 52, 428-436).
|
8443798 |
1993 |