|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
UII inhibition has been considered as beneficial strategy for atherosclerosis and restenosis.
|
28173642 |
2017 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In previous investigations, U-II receptor antagonists have been shown to protect atherosclerosis in cell and animal models.
|
28363746 |
2017 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Since the regulation of the urotensin II/urotensin II receptor offers a great potential for therapeutic strategies related to the treatment of cardiovascular diseases, the study of selective and potent antagonists for urotensin II receptor is more fascinating.
|
28163023 |
2017 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results elucidated for the first time that autocrine UII plays an important role in the development of atherosclerosis by increasing the accumulation of macrophage-derived foam cell.
|
26640798 |
2015 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results elucidated for the first time that autocrine UII plays an important role in the development of atherosclerosis by increasing the accumulation of macrophage-derived foam cell.
|
26640798 |
2015 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Because U-II has been found to be elevated in cardiovascular disorders and in tumour tissues, this feed-forward mechanism could be an interesting anti-angiogenic therapeutic option in these disorders.
|
22399808 |
2012 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis.
|
19111831 |
2009 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis.
|
19111831 |
2009 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis.
|
19111831 |
2009 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, in addition to its primary vasoactive effect, these observations suggest a role of U-II and UT receptor in the initiation and/or progression of atherosclerosis.
|
17933432 |
2008 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, in addition to its primary vasoactive effect, these observations suggest a role of U-II and UT receptor in the initiation and/or progression of atherosclerosis.
|
17933432 |
2008 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Human urotensin II induces tissue factor and cellular adhesion molecules expression in human coronary endothelial cells: an emerging role for urotensin II in cardiovascular disease.
|
18284603 |
2008 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The functional significance of elevated plasma UII levels in CVD is unclear.
|
17900760 |
2008 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
UII may also play a role in renal disease, being elevated in the circulation or urine of patients with renal failure and in experimental models of cardiovascular disease such as the spontaneously hypertensive rat.
|
16807543 |
2006 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
UII may also play a role in renal disease, being elevated in the circulation or urine of patients with renal failure and in experimental models of cardiovascular disease such as the spontaneously hypertensive rat.
|
16807543 |
2006 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings qualitatively and quantitatively demonstrate increased expression of U-II in atherosclerosis with a large degree of inflammatory cell involvement.
|
15306183 |
2004 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that urotensin-II is a locally released vasoactive mediator that may be an important regulator of blood flow particularly to the myocardium and may have a specific role in human atherosclerosis.
|
15476944 |
2004 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings qualitatively and quantitatively demonstrate increased expression of U-II in atherosclerosis with a large degree of inflammatory cell involvement.
|
15306183 |
2004 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Our findings qualitatively and quantitatively demonstrate increased expression of U-II in atherosclerosis with a large degree of inflammatory cell involvement.
|
15306183 |
2004 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that urotensin-II is a locally released vasoactive mediator that may be an important regulator of blood flow particularly to the myocardium and may have a specific role in human atherosclerosis.
|
15476944 |
2004 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Overall analyses indicated that UII gene rs228648 variant was significantly associated with reduced risk of DM (allele, A vs. G: OR = 0.68, 95%CI = 0.56-0.82; dominant, AA+GA vs. GG: OR = 0.70, 95%CI = 0.53-0.91; homozygote, AA vs. GG: OR = 0.41, 95%CI = 0.28-0.61; recessive, AA vs. GA+GG: OR = 0.36, 95%CI = 0.19-0.71).
|
30442870 |
2018 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
The present study explores whether UII can regulate autophagy in the kidney, and its effect in diabetes.
|
27459313 |
2017 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with the risk of developing diabetes and DR. M21M genotype frequencies were high in PDR (8.9% in diabetic control vs. 54.6% in PDR, P = 0.0092) group.
|
22587369 |
2012 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.
|
21559414 |
2011 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
In humans, plasma U-II is elevated in heart failure, renal failure, liver disease, and diabetes.
|
17680191 |
2007 |