|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Sleep Apnea, Obstructive
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Current Treatment of Comorbid Insomnia and Obstructive Sleep Apnea With CBTI and PAP-Therapy: A Systematic Review.
|
30420826 |
2018 |
|
Sleep Apnea, Obstructive
|
0.050 |
Biomarker
|
disease |
BEFREE |
A small percentage of adult patients with severe obstructive sleep apnea (OSA) has been recognized to be extraordinarily difficult to treat with conventional continuous or Bi-level positive airway pressure (together referred to as PAP) therapy.
|
28822020 |
2018 |
|
Sleep Apnea, Obstructive
|
0.050 |
Biomarker
|
disease |
BEFREE |
A prospective study of Veterans with confirmed PTSD and new diagnosis of OSA not yet using PAP therapy were recruited from a Veteran's Affairs sleep medicine clinic.
|
27707436 |
2017 |
|
Sleep Apnea, Obstructive
|
0.050 |
Biomarker
|
disease |
BEFREE |
Serum concentrations of IL-2, IL-4, IL-6, MCP-1, PDGFβ, and VEGFα were reduced by therapeutic c-PAP in OSA subjects and remained unaltered in non-OSA and subtherapeutic c-PAP groups.
|
28878129 |
2017 |
|
Sleep Apnea, Obstructive
|
0.050 |
Biomarker
|
disease |
BEFREE |
Research is warranted on advanced PAP modes in managing CPAP failure in PTSD patients with comorbid OSA.
|
29200833 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
All asymptomatic individuals underwent screening investigations for malignancy including PAP smear, mammography, low-dose computed tomography, evaluation of cancer antigen 125, cancer antigen 19-9, alpha fetoprotein, carcinoembryonic antigen, prostate specific antigen (PSA) levels and clinical examination to identify healthy individuals with no indication of cancer.
|
31785151 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
For this purpose, raw RT-qPCR data for 25 candidate microRNAs, U6 snRNA and human DNA in air-dried PAP smears from 174 women with different cervical cytological diagnoses, 144 of which were HR-HPV-positive [40 negative for intraepithelial lesion or malignancy (NILM), 34 low-grade squamous intraepithelial lesions (L-SIL), 57 high-grade squamous intraepithelial lesions (H-SIL), 43 invasive cancers], were statistically processed.
|
29328473 |
2018 |
|
Human papilloma virus infection
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Urbanization, the number of sex partners, and PAP history appear as risk factors for HPV infection in Han, but not in Mongolian participants.
|
28661048 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In this study, we show that HMGB1 increases the expression of miR-221 and miR-222 in primary cultures of excised papillary lesions and in an established papillary cancer cell line (BC PAP).
|
23023232 |
2012 |
|
Human papilloma virus infection
|
0.040 |
Biomarker
|
disease |
BEFREE |
We evaluated the prevalence of human papillomavirus (HPV) infection and correlated the molecular test results with the cytological examination data (PAP test) in 364 women living in central-southern Italy (Molise region), by means of polymerase chain reaction HPV DNA genotyping and of cervical cytology.
|
20128441 |
2009 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Three genes encoding related proteins, PAP, reg Ialpha and reg Ibeta, were over-expressed in cancer.
|
10328217 |
1999 |
|
Human papilloma virus infection
|
0.040 |
Biomarker
|
disease |
BEFREE |
Human papillomavirus infection test results detected by Southern blot hybridization and polymerase chain reaction from physician-administered and MY-PAP self-administered cervicovaginal lavage were paired for comparison.
|
1332474 |
1992 |
|
Human papilloma virus infection
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Colposcopy, punch biopsy, in situ DNA hybridization, and the polymerase chain reaction in searching for genital human papillomavirus (HPV) infections in women with normal PAP smears.
|
2176670 |
1990 |
|
Cervical Intraepithelial Neoplasia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Cases were categorized as cervical dysplasia only (S2) or cervical dysplasia with conization (S1) and compared to healthy controls with a normal PAP smear.
|
30374649 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
All asymptomatic individuals underwent screening investigations for malignancy including PAP smear, mammography, low-dose computed tomography, evaluation of cancer antigen 125, cancer antigen 19-9, alpha fetoprotein, carcinoembryonic antigen, prostate specific antigen (PSA) levels and clinical examination to identify healthy individuals with no indication of cancer.
|
31785151 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.030 |
Biomarker
|
disease |
BEFREE |
Invasive hemodynamic evaluation showed suprasystemic PAH and marked acute vasoreactivity (PAP 127/103/83 mmHg, PVRi 23.48 WU·m<sup>2</sup> and PVR/SVR ratio 1.59 at baseline vs. PVRi 5.89 WU·m<sup>2</sup> and PVR/SVR ratio 0.93 under O<sub>2</sub>/NO).
|
29099661 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Patients were classified as PAH if echocardiographic systolic pulmonary artery pressure (sPAP) ≥50 mmHg or right heart catheterization (RHC) mean PAP ≥25 mmHg.
|
31810742 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.030 |
Biomarker
|
disease |
BEFREE |
In the RHC subgroup (n=28), mean (m)PAP and pulmonary vascular resistance at 50 W increased significantly (p=0.02 and p=0.002, respectively), but resting mPAP was unchanged.Scleroderma patients without PAH develop a mild but significant deterioration of pulmonary exercise haemodynamics and exercise capacity over a 4-year follow-up period, indicating a progression of pulmonary vascular disease.
|
28705939 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
In this study, we show that HMGB1 increases the expression of miR-221 and miR-222 in primary cultures of excised papillary lesions and in an established papillary cancer cell line (BC PAP).
|
23023232 |
2012 |
|
Cervical Intraepithelial Neoplasia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
: The study included 188 women who consecutively attended a colposcopy clinic because of PAP smears suggesting cervical intraepithelial neoplasia (CIN), and 40 women with normal vaginal cytology.
|
21558960 |
2011 |
|
Cervical Intraepithelial Neoplasia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Performance of the Roche AMPLICOR human papillomavirus (HPV) test in prediction of cervical intraepithelial neoplasia (CIN) in women with abnormal PAP smear.
|
16023184 |
2005 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Three genes encoding related proteins, PAP, reg Ialpha and reg Ibeta, were over-expressed in cancer.
|
10328217 |
1999 |
|
Hodgkin Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Risk-adjusted analyses demonstrated higher PP (adjusted hazard ratio [aHR], 1.32; 95% confidence interval [CI], 1.20-1.45; P < .001), PAP (aHR, 1.32; 95% CI, 1.19-1.45; P < .001), SP (aHR, 1.47; 95% CI, 1.31-1.65; P < .001), limb salvage (aHR, 1.48; 95% CI, 1.30-1.67; P < .001), and patient survival (aHR, 2.42; 95% CI, 2.17-2.71; P < .001) for RT compared with HD patients.
|
30583904 |
2019 |
|
Huntington Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Risk-adjusted analyses demonstrated higher PP (adjusted hazard ratio [aHR], 1.32; 95% confidence interval [CI], 1.20-1.45; P < .001), PAP (aHR, 1.32; 95% CI, 1.19-1.45; P < .001), SP (aHR, 1.47; 95% CI, 1.31-1.65; P < .001), limb salvage (aHR, 1.48; 95% CI, 1.30-1.67; P < .001), and patient survival (aHR, 2.42; 95% CI, 2.17-2.71; P < .001) for RT compared with HD patients.
|
30583904 |
2019 |