|
Degenerative polyarthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.
|
18784066 |
2009 |
|
Osteoarthrosis Deformans
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.
|
18784066 |
2009 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
|
Smoking Behaviors
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
|
Lung Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
|
18794547 |
2008 |
|
Lung Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.
|
18089831 |
2007 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, overexpression of YWHAQ in primary tumor was linked to poor prognosis of patients with HCC.
|
31188160 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The association of YWHAQ with recurrence-free survival of patients with HCC was assessed by Kaplan-Meier analysis.
|
31188160 |
2019 |
|
Sporadic CJD
|
0.010 |
Biomarker
|
disease |
BEFREE |
We analyzed the role of ApoE ε4 in sporadic CJD (sCJD), in particular the influence on the CSF-markers 14-3-3 protein, tau protein, neuron-specific enolase, S100 protein, Aβ1-42, and Aβ1-40.
|
21157024 |
2011 |
|
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Levels of 27 transcripts were investigated as potential novel markers for prostate cancer, including genes encoding plasma membrane proteins (ADAM2, ELOVL5, MARCKSL1, RAMP1, TMEM30A, and TMEM66); secreted proteins (SPON2, TMEM30A, TMEM66, and truncated TMEFF2 (called POP4)); intracellular proteins (CAMK2N1, DHCR24, GLO1, NGFRAP1, PGK1, PSMA7, SBDS, and YWHAQ); and noncoding transcripts (POP1 (100 kb) from mRNA AK000023), POP2 (4 kb from mRNA AL832227), POP3 (50 kb from EST CFI40309), POP5 (intron of NCAM2, accession DO668384), POP6 (intron of FHIT), POP7 (intron of TNFAIP8), POP8 (intron of EFNA5), POP9 (intron of DSTN), POP10 (intron of ADAM2, accession DO668396), POP11 (87kb from EST BG194644), and POP12 (intron of EST BQ226050)).
|
19893039 |
2009 |
|
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Levels of 27 transcripts were investigated as potential novel markers for prostate cancer, including genes encoding plasma membrane proteins (ADAM2, ELOVL5, MARCKSL1, RAMP1, TMEM30A, and TMEM66); secreted proteins (SPON2, TMEM30A, TMEM66, and truncated TMEFF2 (called POP4)); intracellular proteins (CAMK2N1, DHCR24, GLO1, NGFRAP1, PGK1, PSMA7, SBDS, and YWHAQ); and noncoding transcripts (POP1 (100 kb) from mRNA AK000023), POP2 (4 kb from mRNA AL832227), POP3 (50 kb from EST CFI40309), POP5 (intron of NCAM2, accession DO668384), POP6 (intron of FHIT), POP7 (intron of TNFAIP8), POP8 (intron of EFNA5), POP9 (intron of DSTN), POP10 (intron of ADAM2, accession DO668396), POP11 (87kb from EST BG194644), and POP12 (intron of EST BQ226050)).
|
19893039 |
2009 |
|
Creutzfeldt-Jakob disease
|
0.010 |
Biomarker
|
disease |
LHGDN |
[Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia].
|
18626620 |
2008 |
|
Guillain-Barre Syndrome
|
0.010 |
Biomarker
|
disease |
LHGDN |
Detection of CSF 14-3-3 protein in Guillain-Barré syndrome.
|
17190946 |
2006 |
|
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization.
|
16367866 |
2006 |
|
Fibrosis
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.
|
15930726 |
2005 |
|
Cardiomegaly
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.
|
15930726 |
2005 |
|
Prion Diseases
|
0.010 |
Biomarker
|
group |
LHGDN |
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
|
16215457 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis.
|
15022330 |
2004 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results show the marked up-regulation of the 14-3-3 isoform (YWHAQ) in ALS spinal cord and indicate the involvement of a potential 14-3-3-mediated survival pathway in the pathogenesis of ALS.
|
11080204 |
2000 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
To summarize, central TRH overproduction in periventricular areas induced by I.C.V. transfection produces hypertension in rats which is reversed by specific antisense treatment.
|
9323019 |
1997 |