COPS5, COP9 signalosome subunit 5, 10987

N. diseases: 101; N. variants: 1
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression phenotype BEFREE High CSN5 expression level is closely correlated with tumor progression and poor survival in NSCLC patients. 29596838 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression phenotype BEFREE Additionally, we demonstrated that high CSN5 level was closely correlated with tumor progression and poor survival in RCC patients. 28479251 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression phenotype BEFREE Jab1/COPS5 level has been shown to be associated with tumor progression and poor outcomes in many types of cancer patients. 29228627 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE More recent evidence shows that CSN5 and CSN6 are implicated in ubiquitin-mediated proteolysis of important mediators in carcinogenesis and cancer progression. 21876386 2011
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 AlteredExpression phenotype BEFREE Jab1 is known as a coactivator of AP-1 transcription factor, which contributes to tumor progression by degrading the p27 protein. 19349901 2009
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.060 Biomarker phenotype BEFREE These findings suggest that Jab1 protein may contribute to the tumor progression through Jab1-mediated p27kip1 degradation and that control of Jab1 expression is a novel therapeutic target with NHLs. 18285702 2008