|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype.
|
1342710 |
1992 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The nucleotide sequences of a short fragment of the envelope protein gene encoding amino acids 25 to 89 of 27 dengue 3 viruses were determined by direct sequencing of PCR-amplified products, and the viruses were compared regarding their time of isolation and geographic distribution.
|
8277284 |
1993 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nucleic acid sequences of the pre-membrane/membrane and envelope protein genes of 23 geographically and temporally distinct dengue (DEN)-3 viruses were determined.
|
8113741 |
1994 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the genetic variability and to detect evolutionary changes and movement of dengue 2 (DEN-2) strains, nucleotide sequencing of the envelope protein gene and the nonstructural protein 1 gene junction was performed for 9 isolates from the 1996 Delhi epidemic and 1 isolate from the 1967 Delhi epidemic.
|
10479118 |
1999 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The vaccine candidates are chimeric viruses (designated WN/DEN4) bearing the membrane precursor and envelope protein genes of WN on a backbone of dengue 4 virus (DEN4) with or without a deletion of 30 nucleotides (Delta 30) in the 3' noncoding region of DEN4.
|
14517072 |
2003 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.
|
15331733 |
2004 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neurovirulence of four encephalitogenic dengue 3 virus strains isolated in Malaysia (1992-1994) is not attributed to their envelope protein.
|
15099995 |
2004 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation.
|
17459925 |
2007 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we evaluate the recombinant fusion protein containing the domain III of the dengue 1 envelope protein (PD10) in non-human primates (M. fascicularis and rhesus monkeys) and compare the effect of aluminum hydroxide and Freund adjuvant on the immunity induced.
|
18602424 |
2008 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of dengue complex-specific neutralizing epitopes on the envelope protein domain III of dengue 2 virus.
|
19101005 |
2009 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The glycosylated envelope protein of dengue virus, DENV E, is processed in the endoplasmic reticulum of host cells and therefore reliant on host processing functions.
|
19105951 |
2009 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system.
|
20097152 |
2010 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two studies in monkeys, combining recombinant protein PD5 (domain III of the envelope protein from dengue-2 virus, fused to the protein carrier P64k) and the infective dengue virus in the same immunization schedules were carried out.
|
19773190 |
2010 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was aimed at evaluating the genetic stability of a live attenuated West Nile (WN) virus vaccine candidate that was generated by replacing the pre-membrane and envelope protein genes of dengue 4 virus with those from WN.
|
21360544 |
2011 |
|
Dengue Fever
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although the envelope protein of DENV influenced EXO70 expression, the co-expression of pre-membrane and envelope proteins significantly increased the expression levels of EXO70 during DENV infection.
|
21034848 |
2011 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant fusion protein containing domain III of the dengue envelope protein fused to capsid protein from dengue 2 virus was immunogenic and conferred protection in mice against lethal challenge in previously report.
|
22554934 |
2012 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Envelope protein gene sequences of all four dengue serotypes (DENV-1-DENV-4) obtained from human sera in Singapore (2008-2010) revealed that constant viral introductions and in situ evolution contribute to viral diversity in Singapore and play important roles in shaping the epidemiology of dengue in the island state.
|
22036707 |
2012 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dengue-1 envelope protein domain III produced in Pichia pastoris: potential use for serological diagnosis.
|
23993978 |
2013 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The envelope protein (E) of dengue virus binds to receptors present on the host cells through its domain III that has been primarily recognized to bind cell receptors.
|
24324976 |
2013 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
It was previously reported that DIIIC-2 (a fusion protein composed of domain III of the envelope protein and the capsid protein from dengue 2 virus), as an aggregate antigen from a partially purified preparation, induced a functional protective immune response against dengue 2 virus in the mouse encephalitis model.
|
22983185 |
2013 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Atomic-level functional model of dengue virus Envelope protein infectivity.
|
24158478 |
2013 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections.
|
27560782 |
2016 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present work, we have targeted the domain I/III hinge region using four known ligands used for the dengue envelope protein (serotype-2) and have intended to explore the specificity of one ligand R1 (5-(3-chlorophenyl)-N-(2-phenyl-2H-benzo[d][1,2,3]triazol-6-yl)furan-2-carboxamide) that succeeded the dengue inhibition by the molecular dynamics (MD) simulations in conjunction of the molecular docking and the binding free energy calculations.
|
28255859 |
2017 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite antigenic similarities with dengue viruses, structural studies have suggested the extended CD-loop and hydrogen-bonding interaction network within the ZIKV envelope protein contribute to stability differences between the viral families.
|
28968838 |
2017 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Suppressive effect of dengue virus envelope protein domain III on megakaryopoiesis.
|
28622093 |
2017 |