Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest the potential to use HERVs env genes as a diagnosis marker for primary breast cancer, and further studies are needed to identify the mechanism and physiological significance of the reduction of HERV env gene expression during chemotherapy.
|
24964007 |
2014 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
All breast cancer and benign breast samples were negative for MMTV env gene-like DNA.
|
25323846 |
2014 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of detection of the mouse mammary tumor-like virus (MMTV) Env gene in Iranian women breast cancer using real time PCR.
|
23803058 |
2013 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we amplified and sequenced the full-length RNA of the env gene of the type 1 and 2 HERV-K (HML-2) viruses collected from the plasma of seven HIV-1-infected patients over a period of 1 to 3 years and from five breast cancer patients in order to reconstruct the genetic evolution of these viruses.
|
22031938 |
2012 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the status of Wnt-1 in human breast cancers harboring MMTV-like sequences encoding viral envelope (env) genes.
|
20388779 |
2010 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study is an attempt to evaluate the current prevalence of MMTV-like env gene in BC in Tunisian women.
|
18639977 |
2008 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, DNA sequences homologous or closely related to MMTV env gene have been specifically detected in breast cancer tissue from significant numbers of American, Australian, and Tunisian women, suggesting a viral etiology for at least a part of human breast cancer.
|
18551605 |
2008 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MMTV-like env gene sequences were identified in 22 of 59 (37.3%) human breast cancer specimens.
|
16698952 |
2006 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sequences highly similar (>95%) to the mouse mammary tumor virus (MMTV) env gene have been amplified from human DNA samples, including DNA samples from patients with breast cancer (BC) and persons who did not have BC.
|
16276510 |
2005 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated expression of the tumor suppressing protein p53 is associated with the presence of mouse mammary tumor-like env gene sequences (MMTV-like) in human breast cancer.
|
15377846 |
2004 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We did not find any exogenous MMTV env gene sequences in the 50 DNA samples of human breast cancer tissue nor in 22 breast cancer cell lines including MCF-7, which has previously been described as a positive control.
|
12792764 |
2004 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This MMTV-like env gene sequence was expressed in 66% of the env gene-positive human breast cancers.
|
15205319 |
2004 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitation of HERV-K env gene expression and splicing in human breast cancer.
|
12629516 |
2003 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome.
|
14514972 |
2003 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Oncogenic transformation assays using mouse and rat fibroblasts have localized the transforming activity to the Env proteins encoded by these viruses, which require the putative lung and breast cancer tumor suppressor hyaluronidase 2 (Hyal2) to promote virus entry into cells.
|
12584308 |
2003 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have reported previously that a 660-bp sequence homologous to the env gene of the mouse mammary tumor virus, but not to the known endogenous retroviruses, was present in 38% of human breast cancers (Y. Wang et al., Cancer Res., 55: 5173-5179, 1995).
|
11234880 |
2001 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer.
|
11295054 |
2001 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMTV-like env gene sequences in human breast cancer.
|
11266212 |
2001 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have detected by PCR a 660-bp sequence similar to the env gene of MMTV but not to the known endogenous viruses, in 38% of human breast cancers examined (Wang et al., Cancer Res., 55: 5173-5179, 1995).
|
11245493 |
2001 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mouse mammary tumor virus-like ENV gene sequences in human breast tumors and in a lymphoma of a breast cancer patient.
|
10778951 |
2000 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously reported that a 660-bp sequence that is homologous to the env gene of the mouse mammary tumor virus (MMTV) but not to endogenous retroviruses or to other known genes was present in 38% of human breast cancers and in some breast cancer cell lines studied (Y. Wang et al., Cancer Res., 55: 5173-5179, 1995).
|
10473094 |
1999 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of mouse mammary tumor virus-like env gene sequences in human breast cancer.
|
9796992 |
1998 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We were also able to identify in breast cancer DNA a segment of 1.6 kb comprising LTR and env gene sequences, which are homologous to MMTV, but not to the HERs.
|
9152517 |
1997 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ecotropic virus, which normally does not infect human cells, when pseudotyped with the modified envelope protein now crosses species to infect human breast cancer cell lines that overexpress HER-2 (human epidermal growth factor receptor; also called ERBB2) and HER-4 (also called ERBB4), while human breast cancer cell lines expressing low levels of these receptors remain resistant to infection.
|
7568210 |
1995 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
These MMTV env gene-like sequences may play a role in the etiology of a large proportion of human breast cancer.
|
7585568 |
1995 |