|
Asthma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
At this time point, the controls but not asthmatics demonstrated upregulation of SPINK5.
|
28552993 |
2017 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that SPINK5 and ADRB2 haplotypes might play a role in the susceptibility to childhood-onset asthma.
|
25233048 |
2015 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the presence or absence of TSLP minor alleles did not affect asthma risk in subjects without the SPINK5 risk alleles.
|
24831437 |
2014 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
To determine the effects of SPINK5 on asthma related physiological events such as apoptosis, mucus and cytokine production by epithelial cells.
|
22133475 |
2012 |
|
Asthma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
SPINK5 single-nucleotide polymorphisms (SNPs) and SPINK5 expression levels were correlated with CRS without (CRSsNP) and with nasal polyps (CRSwNP), aspirin intolerance, asthma, and allergies.
|
22570283 |
2012 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Coding polymorphisms in SPINK5 exons 13, 14 and 26 have been reported to be associated with atopic dermatitis (AD), asthma and high level of IgE.
|
21585560 |
2012 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In order to determine the role of the SPINK5 in the development of asthma, a case-control study including 669 asthma patients and 711 healthy controls in Han Chinese was conducted.
|
19534795 |
2009 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The negative results in this study suggest that SPINK5 is not associated with asthma or atopic phenotypes in individuals ascertained by a proband with asthma.
|
15753894 |
2005 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Development of a high throughput assay to analyse the polymorphism G1258A (Glu420Lys) in exon 14 of the SPINK5 gene followed by the validation using samples of 235 latex-allergic health care workers (HCWs) with (N=63) and without asthma (N=172), and 80 non-atopic controls.
|
15820494 |
2005 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Atopic carriers of SPINK5 420Lys showed an increased risk for asthma and asthma symptoms (OR 2.06; 95%CI: 1.01-4.20, P=0.047).
|
15005725 |
2004 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Ttransmission disequilibrium tests revealed an association of SPINK5 polymorphisms with AD but not with asthma.
|
14551605 |
2003 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, coding polymorphisms in SPINK5 exons 13 and 14 have been reported to be associated with atopy, asthma and atopic dermatitis (AD).
|
12752122 |
2003 |
|
Asthma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|