Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.320 Biomarker disease BEFREE Thus, we studied whether prolonged HFD causes TNF-α/RIPK3 activation-associated hepatic steatosis, further evaluating the protective effects of Fn in HFD-fed mice. 30793717 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.320 GeneticVariation disease BEFREE RIP3 deletion exacerbates steatosis, and partially inhibits inflammation in the HF diet induced NAFLD model. 30622377 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.320 Therapeutic disease CTD_human In conclusion, results from this study suggest that impaired hepatic proteasome function by alcohol exposure may contribute to hepatic accumulation of RIP3 resulting in necroptosis and steatosis while RIP1 kinase activity is important for alcohol-induced inflammation. 26769846 2016