Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 Biomarker disease BEFREE We propose that Wwp2 has a role in protecting cartilage from OA by suppressing Runx2-induced Adamts5 via Runx2 poly-ubiquitination and degradation. 31160553 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 AlteredExpression disease BEFREE The intronic miR-140, present in the WW domain containing E3 ubiquitin protein ligase 2 (WWP2) gene, decreases the expression of genes that play detrimental roles in osteoarthritis (OA). 24257415 2013
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 Biomarker disease BEFREE Here, it is suggested that WWP2 isoforms have now emerged as central physiological regulators as well as promising new disease targets, and that the challenge ahead is to now develop highly selective WWP2 inhibitors with utility in cartilage disease such as osteoarthritis and as new anticancer strategies. 21750408 2011