Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.120 Biomarker disease BEFREE A serial deletion of the 1.2 kb at the 5'-flanking region of the human HLJ1 gene was subcloned into a vector containing reporter gene and transfected into human lung adenocarcinoma cell line CL1-0, followed by luciferase activity assay. 15782117 2005
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 AlteredExpression group BEFREE Overexpression of HLJ1 can suppress cancer cell invasion in vitro. 15782117 2005
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 AlteredExpression phenotype BEFREE Overexpression of HLJ1 can suppress cancer cell invasion in vitro. 15782117 2005
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 AlteredExpression group BEFREE Overexpression of HLJ1 can suppress cancer cell invasion in vitro. 15782117 2005
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.130 AlteredExpression disease BEFREE HLJ1 expression inhibited lung cancer cell proliferation, anchorage-independent growth, tumorigenesis, cell motility, and invasion, and slowed cell cycle progression through a novel STAT1/P21(WAF1) pathway that is independent of P53 and interferon. 16788156 2006
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.120 AlteredExpression disease BEFREE We induced HLJ1 overexpression or knockdown in human lung adenocarcinoma CL1-5 cells and analyzed cell proliferation, anchorage-independent growth, in vivo tumorigenesis, cell motility, invasion, and cell cycle progression. 16788156 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 AlteredExpression group BEFREE We measured HLJ1 expression in tumors and adjacent normal tissues of 71 NSCLC patients by quantitative reverse transcription-polymerase chain reaction. 16788156 2006
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE We previously identified DnaJ-like heat shock protein (HLJ1) as a gene associated with tumor invasion. 16788156 2006
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.030 GeneticVariation disease BEFREE Loss of heterozygosity (LOH) mapping of the HLJ1 locus was analyzed in 48 paired microdissected NSCLC tumors.All statistical tests were two-sided. 16788156 2006
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.030 AlteredExpression phenotype BEFREE Here, we investigated the clinical significance of HLJ1 expression in non-small-cell lung cancer (NSCLC) patients and its role in cancer progression. 16788156 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE HLJ1 expression inhibited lung cancer cell proliferation, anchorage-independent growth, tumorigenesis, cell motility, and invasion, and slowed cell cycle progression through a novel STAT1/P21(WAF1) pathway that is independent of P53 and interferon. 16788156 2006
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE HLJ1 expression inhibited lung cancer cell proliferation, anchorage-independent growth, tumorigenesis, cell motility, and invasion, and slowed cell cycle progression through a novel STAT1/P21(WAF1) pathway that is independent of P53 and interferon. 16788156 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 AlteredExpression phenotype BEFREE Elucidation of the regulatory mechanism of HLJ1 expression may facilitate the development of personalized therapy by inhibiting cancer cell proliferation, angiogenesis, and metastasis. 17510411 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE HLJ1 is a novel tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis. 17510411 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 AlteredExpression group BEFREE Elucidation of the regulatory mechanism of HLJ1 expression may facilitate the development of personalized therapy by inhibiting cancer cell proliferation, angiogenesis, and metastasis. 17510411 2007
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE HLJ1 is a novel tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis. 17510411 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 AlteredExpression group BEFREE Elucidation of the regulatory mechanism of HLJ1 expression may facilitate the development of personalized therapy by inhibiting cancer cell proliferation, angiogenesis, and metastasis. 17510411 2007
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE HLJ1 is a novel tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis. 17510411 2007
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.130 Biomarker disease BEFREE Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. 18794131 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 AlteredExpression phenotype BEFREE In this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1). 18794131 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 AlteredExpression group BEFREE In this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1). 18794131 2008
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 AlteredExpression group BEFREE In this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1). 18794131 2008
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 AlteredExpression phenotype BEFREE Activation of HLJ1 by curcumin further leads to up-regulation of E-cadherin and a suppression of cancer cell invasion. 18794131 2008
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 AlteredExpression group BEFREE In this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1). 18794131 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 Biomarker disease BEFREE Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. 18794131 2008