|
Abnormal behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
These findings indicate a critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.
|
15514160 |
2004 |
|
Abnormal behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
A length polymorphism repeat in the 5-HTT promoter region, termed 5-HTTLPR, has been commonly investigated for an association with psychiatric disorders.
|
22921522 |
2013 |
|
Alagille Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, we found a significant interaction effect of the SLC6A4 promoter polymorphism (5-HTTLPR) and DRD2 exon 8 single nucleotide polymorphism rs6276 on AWS and/or DT history (P = 0.009), which became more significant after adjustment for lifetime maximum number of drinks consumed per 24 hours (P < 0.001).
|
20002020 |
2010 |
|
Alcohol abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Studies suggest that the short allele of the 5-HTT promoter (5-HTTPR) site can adversely influence the antidepressant response to SSRIs, and is associated with anxiety-related traits, depression, and impulsive disorders such as alcohol abuse.
|
12083964 |
2001 |
|
Alcohol Withdrawal Delirium
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, we found a significant interaction effect of the SLC6A4 promoter polymorphism (5-HTTLPR) and DRD2 exon 8 single nucleotide polymorphism rs6276 on AWS and/or DT history (P = 0.009), which became more significant after adjustment for lifetime maximum number of drinks consumed per 24 hours (P < 0.001).
|
20002020 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.060 |
PosttranslationalModification
|
disease |
BEFREE |
Results did not reveal any association between SLC6A4 promoter methylation variation and threat-related amygdala activation in HCs or individuals with AD.
|
31008507 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The findings in this meta-analysis suggest that the SLC6A4 promoter polymorphism is not associated with alcohol dependence.
|
25710844 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTT promoter genotype was determined by a PCR-based method in 114 late onset (type 1) non-violent alcoholics, 51 impulsive violent recidivistic offenders with early onset alcoholism (type 2), and 54 healthy controls.
|
10483057 |
1999 |
|
Alcoholic Intoxication, Chronic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In our sample, the functional relevant 5-HTT promoter and the 5-HT2c receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
|
14574222 |
2003 |
|
Alcoholic Intoxication, Chronic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The short (S) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR) contributes to the risk of alcohol dependence and co-occurring clinical features.
|
18364363 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the serotonin transporter gene SLC6A4 promoter region appears related to differential treatment response to sertraline depending on the subject's age of onset of alcoholism.
|
22587755 |
2012 |
|
Alexithymia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Serotonin transporter gene promoter polymorphism and alexithymia.
|
22222552 |
2012 |
|
Anorexia Nervosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that the genetic variance of the serotonin transporter gene promoter contributed to the susceptibility of AN.
|
19708070 |
2010 |
|
Anxiety
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the human serotonin transporter gene promoter (5-HTTLPR) is associated with anxiety and increased risk for developing depression in the face of adversity.
|
15302939 |
2004 |
|
Anxiety
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression.
|
17931429 |
2007 |
|
Anxiety
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, it showed that respondents with s/s genotype of the 44-bp polymorphism in the 5-HTT (SLC6A4) promoter region had the highest average anxiety levels both as a state and as a trait.
|
25547397 |
2014 |
|
Anxiety
|
0.060 |
Biomarker
|
disease |
BEFREE |
A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes.
|
28719342 |
2017 |
|
Anxiety
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A deletion/insertion polymorphism within the 5-HT transporter (5-HTT) promoter gene (5-HTT gene-linked polymorphic region, 5-HTTLPR) is thought to be associated with several psychopathological phenotypes related to disturbed impulse control, anxiety and depression.
|
15211560 |
2004 |
|
Anxiety
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The low-expressing allele of the 5-HTT promoter polymorphism (HTTLPR) is associated with anxiety and with greater amygdala and other regional responses to emotional.
|
16595858 |
2006 |
|
Anxiety and fear
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We now report that individuals with one or two copies of the short allele of the serotonin transporter (5-HTT) promoter polymorphism, which has been associated with reduced 5-HTT expression and function and increased fear and anxiety-related behaviors, exhibit greater amygdala neuronal activity, as assessed by BOLD functional magnetic resonance imaging, in response to fearful stimuli compared with individuals homozygous for the long allele.
|
12130784 |
2002 |
|
Anxiety Disorders
|
0.070 |
GeneticVariation
|
group |
BEFREE |
The low-expressing allele of the 5-HTT promoter polymorphism (HTTLPR) is associated with anxiety and with greater amygdala and other regional responses to emotional.
|
16595858 |
2006 |
|
Anxiety Disorders
|
0.070 |
GeneticVariation
|
group |
BEFREE |
A deletion/insertion polymorphism within the 5-HT transporter (5-HTT) promoter gene (5-HTT gene-linked polymorphic region, 5-HTTLPR) is thought to be associated with several psychopathological phenotypes related to disturbed impulse control, anxiety and depression.
|
15211560 |
2004 |
|
Anxiety Disorders
|
0.070 |
Biomarker
|
group |
BEFREE |
A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes.
|
28719342 |
2017 |
|
Anxiety Disorders
|
0.070 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in the human serotonin transporter gene promoter (5-HTTLPR) is associated with anxiety and increased risk for developing depression in the face of adversity.
|
15302939 |
2004 |
|
Anxiety Disorders
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression.
|
17931429 |
2007 |