Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation disease BEFREE The present study investigated the association of 5-HTTLPR polymorphism and CpG DNA methylation (5mC) levels of an AluJb repeat element at the SLC6A4 promoter region in mother-child pairs exposed to maternal depression. 30447571 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 PosttranslationalModification disease BEFREE Hypermethylation of the serotonin transporter gene promoter in panic disorder-Epigenetic imprint of comorbid depression? 31353282 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 PosttranslationalModification disease BEFREE Hypermethylation of the serotonin transporter gene promoter in panic disorder-Epigenetic imprint of comorbid depression? 31353282 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE The present study investigated the association of 5-HTTLPR polymorphism and CpG DNA methylation (5mC) levels of an AluJb repeat element at the SLC6A4 promoter region in mother-child pairs exposed to maternal depression. 30447571 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 PosttranslationalModification phenotype BEFREE Hypermethylation of the serotonin transporter gene promoter in panic disorder-Epigenetic imprint of comorbid depression? 31353282 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE The present study investigated the association of 5-HTTLPR polymorphism and CpG DNA methylation (5mC) levels of an AluJb repeat element at the SLC6A4 promoter region in mother-child pairs exposed to maternal depression. 30447571 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation disease BEFREE Therefore, the effect of 5-HTT promoter variation on the relationship between the loss of parent or partner and depression was examined. 22884012 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 PosttranslationalModification disease BEFREE Higher SLC6A4 promoter methylation status was significantly associated with childhood adversities, worse clinical presentation (family history of depression, higher perceived stress, and more severe psychopathology assessed by SOFAS, WHODAS-12, and WHOQOL-BREF), but was not associated with treatment outcomes after considering multiple comparisons. 23333376 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE Therefore, the effect of 5-HTT promoter variation on the relationship between the loss of parent or partner and depression was examined. 22884012 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 PosttranslationalModification disease BEFREE Higher SLC6A4 promoter methylation status was significantly associated with childhood adversities, worse clinical presentation (family history of depression, higher perceived stress, and more severe psychopathology assessed by SOFAS, WHODAS-12, and WHOQOL-BREF), but was not associated with treatment outcomes after considering multiple comparisons. 23333376 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE Therefore, the effect of 5-HTT promoter variation on the relationship between the loss of parent or partner and depression was examined. 22884012 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 PosttranslationalModification phenotype BEFREE Higher SLC6A4 promoter methylation status was significantly associated with childhood adversities, worse clinical presentation (family history of depression, higher perceived stress, and more severe psychopathology assessed by SOFAS, WHODAS-12, and WHOQOL-BREF), but was not associated with treatment outcomes after considering multiple comparisons. 23333376 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation disease BEFREE The serotonin transporter gene promoter polymorphism (5HTTLPR) and child abuse have been associated with an increased risk for depression. 22311265 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation disease BEFREE The serotonin transporter gene (SLC6A4) promoter polymorphism (5HTTLPR) has been associated with individual stress responses such that individuals with childhood abuse history have higher rates of depression in later life if they are homozygous short (s/s) of the gene. 22236459 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE The serotonin transporter gene (SLC6A4) promoter polymorphism (5HTTLPR) has been associated with individual stress responses such that individuals with childhood abuse history have higher rates of depression in later life if they are homozygous short (s/s) of the gene. 22236459 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE The serotonin transporter gene promoter polymorphism (5HTTLPR) and child abuse have been associated with an increased risk for depression. 22311265 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. 21996278 2012
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE The serotonin transporter gene promoter polymorphism (5HTTLPR) and child abuse have been associated with an increased risk for depression. 22311265 2012
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE The serotonin transporter gene (SLC6A4) promoter polymorphism (5HTTLPR) has been associated with individual stress responses such that individuals with childhood abuse history have higher rates of depression in later life if they are homozygous short (s/s) of the gene. 22236459 2012
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE Increased 2(nd) trimester maternal depressed mood (EPDS scores) was associated with decreased maternal and infant SLC6A4 promoter methylation (p<0.05), but had no effect on BDNF promoter methylation. 20808944 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation disease BEFREE Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. 19016667 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. 19016667 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation disease BEFREE The short (s) allele of the serotonin transporter gene promoter (5-HTTLPR) may be associated with exposure to social adversities and the subsequent onset of depressive illness in adulthood. 19567894 2009
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. 19016667 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation disease BEFREE The serotonin transporter gene (SLC6A4) promoter polymorphism (5-HTTLPR) has been associated with depression, but most consistently in the context of environmental stress. 17460615 2008