|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
rDer p 1 significantly up-regulated the expression of PLA2G4A, PLA2G6, PLA2G15, CYSLTR1, LB4R2, PTGS1, PTGS2, FOXP1, GATA3, HDAC2, IREB2, PPARG, STAT4, TSLP and CHI3L1 genes in asthmatics in comparison to healthy subjects.
|
25634111 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although YKL-40 is expressed in exaggerated quantities and correlates with disease activity in asthma and many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined.
|
19414556 |
2009 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Following adjustment for CHI3L1 genotype, significantly greater levels of YKL-40 were found in children with therapy-resistant asthma than in children with controlled asthma.
|
23628340 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum YKL-40 may be used as a protein marker in classifying asthma severity by applying SPR technology as a reliable, label-free, highly sensitive, and cost-effective tool.
|
27616735 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A highly significant relation between serum levels of periostin and YKL40 and asthma severity, p value for each was <0.001.
|
29970479 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the Tsukuba GWAS cohort, the C allele at rs946261 was significantly associated with reduced expression of CHI3L1 mRNA in the lung and with development of asthma (odds ratio (OR) 1.27; P = 0.036).
|
30940096 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chitinase 3-like 1 protein (CHI3L1) (YKL-40 in humans and breast regression protein [BRP]-39 in mice) is required for optimal allergen sensitization and Th2 inflammation in various chronic inflammatory diseases including asthma.
|
30402955 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variations in CHI3L1 and CHIA have been associated with asthma risk.
|
19644363 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum periostin was high in both asthma and ACO, but not in COPD, whereas serum YKL-40 was high in both COPD and ACO, but not in asthma.
|
29981861 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, a significant correlation with the genotypes in CHI3L1/YKL-40 was observed in the context of stress and asthma severity.
|
23190377 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Less is known about non-type 2 inflammation but blood neutrophils and YKL-40 may be higher in patients with evidence of non-type 2 asthma.
|
31652141 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHI3L1 is a secreted glycoprotein and associated with inflammation, fibrosis, asthma, extracellular tissue remodeling and solid tumors.
|
30121622 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chitinase-like protein YKL-40 has been associated with asthma and lung function in adults, but studies in children have yielded conflicting results.
|
31487401 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore whether interactions between high fungal exposure and common genetic variants in the two chitinases in humans, CHIT1 and CHIA, and the chitinase 3-like 1 gene, CHI3L1, are associated with severe asthma exacerbations and other asthma-related outcomes.
|
20538957 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma.
|
21530869 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum chitotriosidase and YKL-40 were significantly elevated in patients with asthma and those with COPD compared with healthy control subjects.
|
26372680 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found a significant correlation between YKL-40 serum level and spirometric indices even after adjusting the effects of other variables.We report for the first time in an Iranian population that YKL-40 may be a good diagnostic marker of asthma in serum.
|
24659163 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential biomarkers for milder forms of asthma.
|
27193312 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
|
18403759 |
2008 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that CCL18 and YKL-40 levels and CHIT1 activity are enhanced in allergic airway inflammation and thus may contribute to airway remodelling in asthma.
|
23331560 |
2013 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The study had two parts.Study I (n = 115) was a one-year prospective cohort designed to explore the relationship of serum YKL-40 levels with inflammatory phenotypes of asthma at baseline, and during exacerbations.
|
31113430 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to investigate the association of common variation in the CHI3L1 locus with asthma, atopy and lung function in a large population-based sample of adults.
|
19568425 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Completion of the human genome sequence and the advent of genome-wide association studies have resulted in the identification of two novel asthma susceptibility genes, ORMDL3 and CHI3L1, in the past year.
|
18769193 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After stratified according to ethnicity, CHI3L1 rs4950928 variant was associated with decreased asthma risk in Caucasians (GG + GC vs. CC: OR = 0.621, 95% CI = 0.484-0.797, P = 0.000; GC vs. CC: OR = 0.612, 95% CI = 0.470-0.796, P = 0.000; G vs. C: OR = 0.696, 95% CI = 0.567-0.856, P = 0.001).
|
29233108 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The importance of CHI3L1 in initiation and development of asthma is not limited to its involvement in highly orchestrated events of inflammatory cytokines but further research is needed for further elucidation.
|
27438466 |
2016 |