|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
|
18403759 |
2008 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
|
18403759 |
2008 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Completion of the human genome sequence and the advent of genome-wide association studies have resulted in the identification of two novel asthma susceptibility genes, ORMDL3 and CHI3L1, in the past year.
|
18769193 |
2008 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is ample evidence to support an association of acidic mammalian chitinase and YKL-40 with allergic bronchial asthma in patients.
|
19295241 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although YKL-40 is expressed in exaggerated quantities and correlates with disease activity in asthma and many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined.
|
19414556 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, it has been reported that rs10399931 (-329 G/A) of CHI3LI contributes to the inter-individual plasma YKL-40 levels in patients with sarcoidosis, and that rs4950928 (-131 C/G) is a susceptibility polymorphism for asthma and a decline in lung function.
|
19421404 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to investigate the association of common variation in the CHI3L1 locus with asthma, atopy and lung function in a large population-based sample of adults.
|
19568425 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variations in CHI3L1 and CHIA have been associated with asthma risk.
|
19644363 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore whether interactions between high fungal exposure and common genetic variants in the two chitinases in humans, CHIT1 and CHIA, and the chitinase 3-like 1 gene, CHI3L1, are associated with severe asthma exacerbations and other asthma-related outcomes.
|
20538957 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma.
|
21530869 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chitinase-like protein YKL-40 was found to be increased in patients with severe asthma and chronic obstructive pulmonary disease (COPD), two disease conditions featuring neutrophilic infiltrates.
|
21949714 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, a significant correlation with the genotypes in CHI3L1/YKL-40 was observed in the context of stress and asthma severity.
|
23190377 |
2013 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that CCL18 and YKL-40 levels and CHIT1 activity are enhanced in allergic airway inflammation and thus may contribute to airway remodelling in asthma.
|
23331560 |
2013 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Following adjustment for CHI3L1 genotype, significantly greater levels of YKL-40 were found in children with therapy-resistant asthma than in children with controlled asthma.
|
23628340 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found a significant correlation between YKL-40 serum level and spirometric indices even after adjusting the effects of other variables.We report for the first time in an Iranian population that YKL-40 may be a good diagnostic marker of asthma in serum.
|
24659163 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the CHI3L1 polymorphisms rs1538372 and rs10399931 can be used as genetic markers for predicting asthma risk in the Taiwanese population.
|
25056157 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the promoter SNP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function, and YKL-40 expression in the blood and airway.
|
25592985 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
rDer p 1 significantly up-regulated the expression of PLA2G4A, PLA2G6, PLA2G15, CYSLTR1, LB4R2, PTGS1, PTGS2, FOXP1, GATA3, HDAC2, IREB2, PPARG, STAT4, TSLP and CHI3L1 genes in asthmatics in comparison to healthy subjects.
|
25634111 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum chitotriosidase and YKL-40 were significantly elevated in patients with asthma and those with COPD compared with healthy control subjects.
|
26372680 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential biomarkers for milder forms of asthma.
|
27193312 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The importance of CHI3L1 in initiation and development of asthma is not limited to its involvement in highly orchestrated events of inflammatory cytokines but further research is needed for further elucidation.
|
27438466 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum YKL-40 may be used as a protein marker in classifying asthma severity by applying SPR technology as a reliable, label-free, highly sensitive, and cost-effective tool.
|
27616735 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma YKL-40 levels were examined in relation to CHI3L1 rs4950928 genotype and clinical characteristics including Asthma Predictive Index, medication use, time spent with respiratory symptoms, atopic status, and blood leukocytes.
|
27732738 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-40 levels in the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) are associated with asthma in early childhood.
|
28739286 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The YKL-40 clusters are potentially useful for identification of individuals with severe or exacerbation-prone asthma.
|
29025889 |
2017 |