CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Disease: Bronchial Hyperreactivity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.020 GeneticVariation disease BEFREE Interestingly, the C-allele of the -131 C-->G (rs4950928) polymorphism of CHI3L1 has been shown to associate with bronchial hyperresponsiveness and reduced lung function suggesting that variations in CHI3L1 may influence risk of asthma. 19568425 2009
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.020 Biomarker disease BEFREE CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function. 18403759 2008