|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
The serine/threonine kinase receptor-associated protein (STRAP), a scaffold protein, was recently shown to facilitate the aberrant activation of Wnt/β-catenin signaling in colorectal cancers.
|
30257989 |
2019 |
|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of STRAP and MELK may be markers of CRC and their disassociation may be a determinant of therapeutic efficacy.
|
29783958 |
2018 |
|
Colorectal Carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Overall, our findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer, with potential implications to improve treatment of this disease.<i></i>.
|
28827371 |
2017 |
|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Here, in order to investigate the roles of STRAP in colorectal carcinogenesis, the expression of the STRAP protein was investigated in 59 colonic adenomas and 123 colorectal cancers by immunohistochemistry.
|
17316412 |
2007 |
|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We have found that normal EWS protein is up-regulated in human cancers, which correlates with the up-regulation of STRAP in 71% of colorectal cancers and 54% of lung cancers, suggesting a cooperative role of these two proteins in human cancers.
|
17108118 |
2006 |
|
Colorectal Carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer.
|
15720808 |
2005 |
|
Colorectal Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
Overexpression of serine-threonine receptor kinase-associated protein in colorectal cancers.
|
17316412 |
2007 |
|
Colorectal Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer.
|
15720808 |
2005 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The presence of STRAP enhances osteosarcoma cell invasion, migration and re-implantation ability, factors which play a critical role in metastasis.
|
30276452 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we report that aberrant downregulation of STRAP in hepatocellular carcinoma (HCC) facilitated tumor cell growth and metastasis in a phosphatase and tensin homologue (PTEN)-dependent manner.
|
29283497 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In addition to its biological roles, this review also focuses on the dual functions of STRAP in cancers displaying redox dysregulation, where it can behave as a tumor suppressor or an oncogene (i.e., it can either inhibit or promote tumor formation), depending on the cellular context.
|
29849900 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In addition, STRAP silencing reduced the success rate of tumor implantation and growth of MNNG-HOS cells in CAM model.
|
30276452 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Through detecting the expression of some tumor-related genes using western blot analysis, we found the tumor suppressor PTEN was decreased upon STRAP silencing.
|
29283497 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The signaling scaffold protein STRAP is upregulated in several cancers, where it promotes tumorigenicity and metastasis.
|
28827371 |
2017 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Together, these results show that the increased STRAP protein levels observed in HCC provide growth advantage among others by enhancing Wnt/β-catenin signaling.
|
30257989 |
2019 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Overexpression and misregulation of STRAP contributes to various carcinomas that are now recognized as therapeutic targets especially for colorectal and lung cancers.
|
29797604 |
2018 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overexpression and misregulation of STRAP contributes to various carcinomas that are now recognized as therapeutic targets especially for colorectal and lung cancers.
|
29797604 |
2018 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These findings strongly suggest that STRAP plays an inhibitory role in HCC via regulating PTEN expression and could be a potential therapeutic target for this disease.© 2017 IUBMB Life, 70(2):120-128, 2018.
|
29283497 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK.
|
29783958 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Silencing STRAP sensitized colorectal cancer cells to chemotherapeutic drugs <i>in vitro</i> and <i>in vivo</i> STRAP depletion also contributed to a reduced stem-like phenotype of colorectal cancer cells, as indicated by reduced expression of the CSC signature and NOTCH signaling regulators <i>in vitro</i> and by diminished tumorigenesis <i>in vivo</i> Genes encoding some upstream activators of NOTCH were highly enriched for H3K27me3, which forms repressive chromatin domains upon STRAP silencing.
|
28827371 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overall, our findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer, with potential implications to improve treatment of this disease.<i></i>.
|
28827371 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data suggested that some of the genes including PKM2, STRAP and FLT3, may participate in the pathology of lung adenocarcinoma metastasis and could be applied as potential markers or therapeutic targets for lung adenocarcinoma.
|
26781266 |
2016 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
STRAP is up-regulated in 60% colon and in 78% lung carcinomas.
|
16778189 |
2006 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of STRAP in A549 lung adenocarcinoma cell line inhibits TGF-beta-induced growth inhibition and enhances anchorage-independent growth of these cells.
|
16778189 |
2006 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We have found that normal EWS protein is up-regulated in human cancers, which correlates with the up-regulation of STRAP in 71% of colorectal cancers and 54% of lung cancers, suggesting a cooperative role of these two proteins in human cancers.
|
17108118 |
2006 |