Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE Silencing STRAP sensitized colorectal cancer cells to chemotherapeutic drugs <i>in vitro</i> and <i>in vivo</i> STRAP depletion also contributed to a reduced stem-like phenotype of colorectal cancer cells, as indicated by reduced expression of the CSC signature and NOTCH signaling regulators <i>in vitro</i> and by diminished tumorigenesis <i>in vivo</i> Genes encoding some upstream activators of NOTCH were highly enriched for H3K27me3, which forms repressive chromatin domains upon STRAP silencing. 28827371 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. 16778189 2006