Disease: Malignant transformation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.040 PosttranslationalModification phenotype BEFREE The observed aberrant methylation frequencies of the RASSF1A and APC gene promoters indicate that an accumulation of epigenetic events at these specific TSG promoters may be associated with the malignant transformation of benign cystadenomas and LMP tumours to carcinomas. 23055343 2012
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.040 Biomarker phenotype BEFREE Taken together, these data show that depletion of RASSF1A could be an early event observed during senescence of normal uveal melanocytes and that additional alterations are acquired during malignant transformation to uveal melanoma. 21788308 2011
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.040 PosttranslationalModification phenotype BEFREE Hypermethylation and inactivation of RASSF1A, however, could be a later event in malignant transformation. 19695681 2009
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.040 AlteredExpression phenotype BEFREE Our findings highlight p53 as a prognostic factor of HCC and RASSF1A as a potential target in preventing malignant transformation of hepatocytes. 18358501 2008