CHKA, choline kinase alpha, 1119

N. diseases: 64; N. variants: 3
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.210 Biomarker disease BEFREE The combination of 5-FU with ChoKα inhibitors resulted in a synergistic effect in vitro in three different human colon cancer cell lines, and in vivo against human colon xenografts in nude mice. 23762272 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.210 Biomarker disease RGD This study is the first to demonstrate increased choline kinase alpha enzymatic activity, protein levels, and mRNA levels in DMH-induced colon cancer as well as human colon cancer, although phosphocholine was not increased in DMH-induced rat cancer. 10622531 1999